MRI联合超声对乳腺癌淋巴结转移的诊断价值：一项Meta分析方案
Diagnostic value of MRI combined with ultrasound for lymph node metastasis in breast cancer: Protocol for a meta-analysis.
作者信息
Cai Dechun, Lin Tong, Jiang Kailin, Sun Zhizhong
机构信息
The First Affiliated Hospital of Guangzhou University of Chinese Medicine.
Guangzhou University of Chinese Medicine, Guangzhou, China.
出版信息
Medicine (Baltimore). 2019 Jul;98(30):e16528. doi: 10.1097/MD.0000000000016528.
BACKGROUND
Early diagnosis and treatment of breast cancer are important to prevent fatal tumor progression. Axillary lymph node (ALN) status is the most significant prognostic factor for diagnosing overall survival in breast cancer patients. Axillary lymph node dissection (ALND) is regarded as the reference standard for determining ALN status. However, ALND is an invasive therapy with high morbidity and complications such as lymphedema, seroma and nerve injury. Comparatively, magnetic resonance imaging (MRI) and ultrasound are noninvasive and non-radiative techniques that are common imaging methods to diagnose breast cancer lymph node metastasis. Many studies have investigated the diagnostic value of MRI combined with ultrasound for breast cancer ALN metastasis, but the evidence has been insufficient to apply these modalities when diagnosing new patients.
METHODS
We will search electronic databases including PubMed, EMbase, The Cochrane Library, Chinese Biomedical Database, WangFang Database, and China National Knowledge Infrastructure. The language of studies is limited in English or Chinese. The final search includes articles published in June, 2018. Stata 14.0 software will be used for all statistical analyses, and Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) will be utilized to evaluate the quality of the included studies. Meta-regression and subgroup analyses will be performed to explore heterogeneity, which will be derived from the different countries of origin of the included studies. Deeks' funnel plot asymmetry test will be demonstrated the inexistence of publication bias.
RESULT
This study will provide a rational synthesis of current evidences for magnetic resonance imaging combined with ultrasound for breast cancer.
CONCLUSION
The conclusion of this study will provide evidence for the diagnostic value of MRI combined with ultrasound for lymph node metastasis in breast cancer.
REGISTRATION
PROS-PERO CRD42019134474.
背景
乳腺癌的早期诊断和治疗对于预防致命的肿瘤进展至关重要。腋窝淋巴结（ALN）状态是诊断乳腺癌患者总生存期的最重要预后因素。腋窝淋巴结清扫术（ALND）被视为确定ALN状态的参考标准。然而，ALND是一种侵入性治疗，具有较高的发病率和诸如淋巴水肿、血清肿和神经损伤等并发症。相比之下，磁共振成像（MRI）和超声是无创且无辐射的技术，是诊断乳腺癌淋巴结转移的常用成像方法。许多研究探讨了MRI联合超声对乳腺癌ALN转移的诊断价值，但证据不足以在诊断新患者时应用这些方法。
方法
我们将检索包括PubMed、EMbase、Cochrane图书馆、中国生物医学数据库、万方数据库和中国知网在内的电子数据库。研究语言限于英语或中文。最终检索包括2018年6月发表的文章。所有统计分析将使用Stata 14.0软件，诊断准确性研究质量评估（QUADAS-2）将用于评估纳入研究的质量。将进行Meta回归和亚组分析以探索异质性，异质性将源于纳入研究的不同国家来源。Deeks漏斗图不对称检验将证明不存在发表偏倚。
结果
本研究将为磁共振成像联合超声诊断乳腺癌提供当前证据的合理综合。
结论
本研究的结论将为MRI联合超声对乳腺癌淋巴结转移的诊断价值提供证据。
注册
PROSPERO CRD42019134474
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