Laboratório de Bioinformática e Biologia Evolutiva, Departamento de Genética, Centro de Biociências, UFPE, Recife, PE 50030-440, Brazil.
Laboratory of Microbiology and Molecular Biology, Center for Biological and Health Sciences, Regional University of Cariri, URCA, Crato, CE 63100-160, Brazil.
Chem Biodivers. 2019 Sep;16(9):e1900344. doi: 10.1002/cbdv.201900344. Epub 2019 Aug 20.
The aim of this study was to investigate the antibacterial activity of red propolis and resin and their association with standard antibiotics to evaluate possible differences of activity. We also submitted red propolis and the resin to a HPLC analysis to confirm the botanical origin. The extracts were tested against P. aeruginosa and S. aureus alone and in association with gentamicin and imipenem. The HPLC analysis identified seven compounds with six of them present in both substances. The lowest MIC values obtained in this study were observed against S. aureus. In general, MIC values showed to be lower for red propolis against all species tested in comparison to resin. Despite the synergistic behavior to be similar for both substances, we observed that inhibitory concentrations of drugs were lower when associated with red propolis in comparison to resin.
本研究旨在探讨红蜂胶和树脂的抗菌活性及其与标准抗生素的联合作用，以评估其可能的活性差异。我们还对红蜂胶和树脂进行了 HPLC 分析，以确认其植物来源。提取物单独或与庆大霉素和亚胺培南联合测试对铜绿假单胞菌和金黄色葡萄球菌的活性。HPLC 分析鉴定了七种化合物，其中六种存在于两种物质中。本研究中获得的最低 MIC 值是针对金黄色葡萄球菌。一般来说，与树脂相比，红蜂胶对所有测试的物种的 MIC 值都较低。尽管两种物质的协同作用相似，但我们观察到与树脂相比，当与红蜂胶联合使用时，药物的抑制浓度较低。
