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神经再生的纳米医学工程：发光二极管介导的超顺磁性氧化铁-金核壳纳米粒子，通过神经生长因子功能化。

Engineered nanomedicine for neuroregeneration: light emitting diode-mediated superparamagnetic iron oxide-gold core-shell nanoparticles functionalized by nerve growth factor.

机构信息

J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX.

Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY.

出版信息

Nanomedicine. 2019 Oct;21:102052. doi: 10.1016/j.nano.2019.102052. Epub 2019 Jul 23.

DOI:10.1016/j.nano.2019.102052
PMID:31349088
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6814551/
Abstract

This paper reports nerve growth factor functionalized superparamagnetic iron oxide-gold core-shell nanoparticles (NGF-SPIO-Au NPs), an engineered nanomedicine for non-invasive neuron regeneration when irradiated by a low-intensity light-emitting diode (LED). NGF-SPIO-Au NPs of 20 μg/ml, were tested on PC-12 neuron-like cells, irradiated by LEDs (525 nm, 1.09, 1.44, and 1.90 mW/cm). A remarkable Ca influx was detected in differentiated PC-12 cells treated with NPs, irradiated by LED of 1.90 and 1.44 mW/cm with great cell viability (>84%) and proliferations. The strong heat generated through their plasmonic surface upon LED irradiation on NGF-SPIO-Au NPs was observed. For cells treated with LED (1.90 mW/cm) and NGF-SPIO-Au NPs, a dramatic enhancement of neuronal differentiation (83%) and neurite outgrowth (51%) was found, and the upregulation of both the neural differentiation specific marker (β3-tubulin) and the cell adhesive molecule (integrin β1) was observed by the reverse transcription-polymerase chain reaction and western blot analysis.

摘要

本文报道了神经生长因子功能化超顺磁性氧化铁-金核壳纳米粒子（NGF-SPIO-Au NPs），这是一种工程纳米医学药物，可在低强度发光二极管（LED）照射下进行非侵入性神经元再生。将 20 μg/ml 的 NGF-SPIO-Au NPs 用于经 LED（525nm、1.09、1.44 和 1.90mW/cm）照射的 PC-12 神经元样细胞。在经 1.90 和 1.44mW/cm LED 照射并用 NPs 处理的分化 PC-12 细胞中检测到明显的 Ca 内流，细胞活力（>84%）和增殖率非常高。在 NGF-SPIO-Au NPs 上的等离子体表面通过 LED 照射产生了强烈的热量。对于用 LED（1.90mW/cm）和 NGF-SPIO-Au NPs 处理的细胞，发现神经元分化（83%）和神经突生长（51%）显著增强，并且通过逆转录-聚合酶链反应和 Western blot 分析观察到神经分化特异性标记物（β3-微管蛋白）和细胞黏附分子（整合素β1）的上调。

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[3]
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[4]
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[5]
Oriented artificial niche provides physical-biochemical stimulations for rapid nerve regeneration.

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[6]
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Int J Nanomedicine. 2023

[7]
Inorganic Nanomaterials versus Polymer-Based Nanoparticles for Overcoming Neurodegeneration.

Nanomaterials (Basel). 2022-7-7

[8]
Progress, Opportunities, and Challenges of Magneto-Plasmonic Nanoparticles under Remote Magnetic and Light Stimulation for Brain-Tissue and Cellular Regeneration.

Nanomaterials (Basel). 2022-6-29

[9]
Superparamagnetic Iron Oxide Nanoparticles: Cytotoxicity, Metabolism, and Cellular Behavior in Biomedicine Applications.

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[10]
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本文引用的文献

[1]
Thermocouple-tip-exposing temperature assessment technique for evaluating photothermal conversion efficiency of plasmonic nanoparticles at low laser power density.

Rev Sci Instrum. 2019-9

[2]
LEDs for photons, physiology and food.

Nature. 2018-11-21

[3]
Promoting neuroregeneration by applying dynamic magnetic fields to a novel nanomedicine: Superparamagnetic iron oxide (SPIO)-gold nanoparticles bounded with nerve growth factor (NGF).

Nanomedicine. 2018-4-5

[4]
Gold nanostar-mediated neural activity control using plasmonic photothermal effects.

Biomaterials. 2017-10-27

[5]
Folic acid conjugated PEG coated gold-iron oxide core-shell nanocomplex as a potential agent for targeted photothermal therapy of cancer.

Artif Cells Nanomed Biotechnol. 2017-10-10

[6]
Recent developments in the synthesis, properties, and biomedical applications of core/shell superparamagnetic iron oxide nanoparticles with gold.

Biomater Sci. 2017-10-24

[7]
SPIO-Au core-shell nanoparticles for promoting osteogenic differentiation of MC3T3-E1 cells: Concentration-dependence study.

J Biomed Mater Res A. 2017-9-19

[8]
Multifunctional gold coated iron oxide core-shell nanoparticles stabilized using thiolated sodium alginate for biomedical applications.

Mater Sci Eng C Mater Biol Appl. 2017-5-14

[9]
How does calcium interact with the cytoskeleton to regulate growth cone motility during axon pathfinding?

Mol Cell Neurosci. 2017-7-29

[10]
A magnetic polypyrrole/iron oxide core/gold shell nanocomposite for multimodal imaging and photothermal cancer therapy.

Talanta. 2017-4-25

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