Department of Toxicology, Faculty of Pharmacy, Hacettepe University , Ankara , Turkey.
Department of Toxicology, Faculty of Pharmacy, Ataturk University , Erzurum , Turkey.
Toxicol Mech Methods. 2019 Nov;29(9):633-643. doi: 10.1080/15376516.2019.1646367. Epub 2019 Aug 20.
In this study, we aimed to investigate whether bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) exposure have any association with Hashimoto's thyroiditis (HT) and its biomarkers and to determine whether oxidative stress biomarkers and trace element levels showed any alterations in children with HT. We found that superoxide dismutase and glutathione peroxidase activities are lower in HT group from control (24% and 46%, respectively, < 0.05). Zinc levels were significantly lower in HT group vs. control. In addition, the levels of mono-(2-ethylhexyl) phthalate (MEHP) which is the primary metabolite for DEHP, were markedly higher in HT group compared to control ( < 0.05). A negative correlation was observed between urinary BPA levels and fT4. In children with HT, oxidant/antioxidant balance is changed and these differences may be related by EDC exposure, the importance of which should be elucidated with further studies.
在这项研究中，我们旨在探讨双酚 A（BPA）和邻苯二甲酸二（2-乙基己基）酯（DEHP）暴露是否与桥本甲状腺炎（HT）及其生物标志物有关，并确定 HT 患儿的氧化应激生物标志物和微量元素水平是否发生变化。我们发现，超氧化物歧化酶和谷胱甘肽过氧化物酶活性在 HT 组中低于对照组（分别为 24%和 46%，均<0.05）。锌水平在 HT 组明显低于对照组。此外，DEHP 的主要代谢物单（2-乙基己基）邻苯二甲酸酯（MEHP）的水平在 HT 组中明显高于对照组（均<0.05）。尿中 BPA 水平与游离 T4 呈负相关。在 HT 患儿中，氧化还原平衡发生变化，这些差异可能与 EDC 暴露有关，这一点需要通过进一步的研究来阐明。
