Choukairi Zineb, Hazzaz Tahar, Lkhider Mustapha, Ferrandez Jose Manuel, Fechtali Taoufiq
Laboratory of Biosciences, Functional, integrated and molecular exploration, School Of Sciences and Technology - Mohammedia, Hassan II University of Casablanca.
Laboratory Of "Inteligencia Ambiental", Polytechnic University of Cartagena, Spain.
Bioinformation. 2019 Mar 15;15(3):172-178. doi: 10.6026/97320630015172. eCollection 2019.
Anxiety, the illness of our time, is one of the most prevalent and co-morbid psychiatric disorder that represents a significant socioeconomic burden. Conventional treatment is associated with a number of side effects and there is a need to develop new therapeutic strategies. Therefore, it is of interest to investigate the modulating effects of Salvia Officinalis L. and Rosmarinus Officinalis L. leaves extracts on anxiety using different behavioral tests, and on neural activity using the Multi-electrode array technique. Data shows the decrease of the time of the immobility associated with a significant increase in the time spent in the center of the open field arena in the treated animals compared to the controls. The number of buried marbles has also decreased in the treated animals in the marble-burying test. On the other hand results also show a decrease of the neural activity explained by a decrease of the number of spikes after 24,48 and 72 h following the addition of 12,5 µg/ml of the plant leaf extracts to the neural culture. However, there were no spikes after the administration of 25µg/ml of the plants extracts.
焦虑症，这个属于我们这个时代的病症，是最普遍且共病的精神疾病之一，给社会经济带来了沉重负担。传统治疗方法存在诸多副作用，因此需要开发新的治疗策略。所以，利用不同行为测试研究鼠尾草叶提取物和迷迭香叶提取物对焦虑的调节作用，并使用多电极阵列技术研究其对神经活动的调节作用，是很有意义的。数据显示，与对照组相比，经处理的动物在旷场中央停留时间显著增加，而静止不动时间减少。在埋珠试验中，经处理的动物埋珠数量也有所减少。另一方面，结果还显示，在神经培养物中添加12.5微克/毫升植物叶提取物后24、48和72小时，神经活动减少，表现为尖峰数量减少。然而，给予25微克/毫升植物提取物后则没有尖峰出现。
