Malik Nishat, Amber Sanila, Zahid Saadia
Neurobiology Research Laboratory, Department of Healthcare Biotechnology, Atta Ur Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
Front Pharmacol. 2022 Aug 12;13:943163. doi: 10.3389/fphar.2022.943163. eCollection 2022.
Alzheimer's disease (AD) is a neurological illness that causes severe cognitive impairment. AD patients also experience at least one of the neuropsychiatric symptoms including apathy, depression, and anxiety during the course of their life. Acetylcholine esterase inhibitors are the available treatment options to alleviate cognitive deficits, whereas methylphenidate (MPH), a psychostimulant, is considered for the treatment of apathy in AD patients. , a perennial herb, has been potentially known to have antioxidant and anti-inflammatory properties. The present study investigated the potential effects of MPH and in comparison with the standard drug, Donepezil, on cognition, anxiety, and depression in the AlCl-induced mouse model of AD. The animals were divided into eight groups (n = 8, each). The results revealed that the MPH- and -treated groups significantly improved memory impairment, whereas substantially reduced depression and anxiety as compared with other treatment groups. MPH treatment induced an antidepressant effect and increased anxiety-like behavior. Moreover, the AlCl exposure led to the formation of amyloid beta (Aβ) plaques in mice hippocampus; however, none of the tested drugs caused a significant reduction in amyloid burden at the selected doses. The present study suggested the potential of to improve memory as well as neuropsychiatric symptoms in AD. Although improved cognitive abilities, it did not reduce the amyloid plaque burden, which indicates that the memory-enhancing effects of are due to some alternate mechanism that needs to be explored further.
阿尔茨海默病（AD）是一种导致严重认知障碍的神经疾病。AD患者在其病程中还会经历至少一种神经精神症状，包括冷漠、抑郁和焦虑。乙酰胆碱酯酶抑制剂是目前可用于缓解认知缺陷的治疗选择，而精神振奋药哌甲酯（MPH）则被考虑用于治疗AD患者的冷漠症状。[此处原文缺失植物名称]，一种多年生草本植物，已知可能具有抗氧化和抗炎特性。本研究调查了MPH和[此处原文缺失植物名称]与标准药物多奈哌齐相比，对氯化铝诱导的AD小鼠模型的认知、焦虑和抑郁的潜在影响。将动物分为八组（每组n = 8）。结果显示，与其他治疗组相比，MPH和[此处原文缺失植物名称]治疗组显著改善了记忆障碍，而[此处原文缺失植物名称]显著降低了抑郁和焦虑。MPH治疗产生了抗抑郁作用并增加了焦虑样行为。此外，氯化铝暴露导致小鼠海马体中淀粉样β（Aβ）斑块的形成；然而，在所选择的剂量下，没有一种受试药物能使淀粉样蛋白负荷显著降低。本研究表明[此处原文缺失植物名称]在改善AD的记忆以及神经精神症状方面具有潜力。尽管[此处原文缺失植物名称]提高了认知能力，但它并没有降低淀粉样斑块负荷，这表明[此处原文缺失植物名称]的记忆增强作用是由于某种需要进一步探索的替代机制。
