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撤回:慢病毒介导的骨膜蛋白沉默通过整合素信号通路对肺癌肿瘤微环境和骨转移的影响

RETRACTED: Effects of lentivirus-mediated silencing of Periostin on tumor microenvironment and bone metastasis via the integrin-signaling pathway in lung cancer.

作者信息

Che Jing, Shen Wen-Zhuang, Deng Yu, Dai Yu-Hong, Liao Yong-De, Yuan Xiang-Lin, Zhang Peng

机构信息

Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China; College of Life Sciences, Wuhan University, Wuhan 430072, PR China.

Department of General Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.

出版信息

Life Sci. 2017 Aug 1;182:10-21. doi: 10.1016/j.lfs.2017.05.030. Epub 2017 Jun 7.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. Concern was raised about the reliability of the Western blot results in Figures 1B, 3B, 5B, and 8A which appear to have a similar phenotype as seen in many other publications, as detailed here: https://pubpeer.com/publications/E266A07D28435DB334E8777CAC97E3; and here: https://docs.google.com/spreadsheets/d/1r0MyIYpagBc58BRF9c3luWNlCX8VUvUuPyYYXzxWvgY/edit#gid=262337249. In addition, a portion of Figure 6B, ‘NC’ group appears to contain image similarities with Figure 6B, ‘si-Integrin-αvβ3’ group, and a portion of Figure 6B, ‘Blank’ group appears to contain image similarities with Figure 6B, ‘NC’ group. The journal requested that the corresponding author comment on these concerns and provide the raw data. However, the authors were not able to satisfactorily fulfill this request and therefore the Editor-in-Chief decided to retract the article.

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