Nishina Kuniyuki, Takagishi Haruto, Takahashi Hidehiko, Sakagami Masamichi, Inoue-Murayama Miho
Graduate School of Brain Sciences, Tamagawa University, Tokyo, Japan.
Brain Science Institute, Tamagawa University, Tokyo, Japan.
Front Hum Neurosci. 2019 Jul 9;13:230. doi: 10.3389/fnhum.2019.00230. eCollection 2019.
Oxytocin (OXT) is known to play an important role in trust, whereas the involvement of other peptide hormones has not been evaluated. In this study, we focused on microsatellite polymorphisms in the intron of the arginine-vasopressin receptor 1a () gene and examined whether the association between the repeat lengths in the intron of is associated with trust and reciprocity in humans. Four-hundred and thirty-three participants played the trust game, answered the attitudinal trust question, and their buccal cells were collected. Results showed that men with a short form of tend to send more money to the opponent, even if there is a possibility of being betrayed by the opponent. Additionally, people with a short form of tended to return money to the opponent who trusts them. However, attitudinal trust was not associated with . These results indicate that arginine-vasopressin receptor 1a plays an important role in trust and reciprocal behaviors.
已知催产素（OXT）在信任中发挥重要作用，而其他肽类激素的作用尚未得到评估。在本研究中，我们聚焦于精氨酸加压素受体1a（AVPR1a）基因内含子中的微卫星多态性，并研究了AVPR1a内含子重复长度之间的关联是否与人类的信任和互惠行为相关。433名参与者进行了信任游戏，回答了态度信任问题，并采集了他们的颊细胞。结果显示，具有短形式AVPR1a的男性倾向于向对手发送更多金钱，即使存在被对手背叛的可能性。此外，具有短形式AVPR1a的人倾向于向信任他们的对手还钱。然而，态度信任与AVPR1a无关。这些结果表明，精氨酸加压素受体1a在信任和互惠行为中起重要作用。
