炎症性肠病中免疫球蛋白重链同种异型的关联与连锁研究。

Association and linkage studies of immunoglobulin heavy chain allotypes in inflammatory bowel disease.

作者信息

Gudjonsson H, Schanfield M S, Albertini R J, McAuliffe T L, Beeken W L, Krawitt E L

机构信息

Department of Medicine, University of Vermont, Burlington.

出版信息

Tissue Antigens. 1988 May;31(5):243-9. doi: 10.1111/j.1399-0039.1988.tb02090.x.

DOI:10.1111/j.1399-0039.1988.tb02090.x

PMID:3135639

Abstract

Inflammatory bowel disease is a familial disorder of unknown etiology, characterized by a variety of immunological abnormalities for which there are no proven genetic markers. Studies of immunoglobulin heavy chain and light chain allotypes were undertaken in 89 patients with Crohn's disease and in 18 families with ulcerative colitis or Crohn's disease in at least two first-degree relatives, to search for association and/or linkage between a postulated disease susceptibility locus and an immunoglobulin allotype locus. No evidence of association or linkage with a specific immunoglobulin allotype was found.

摘要

炎症性肠病是一种病因不明的家族性疾病，其特征是存在多种免疫异常，但尚无经证实的遗传标记。对89例克罗恩病患者以及18个至少有两名一级亲属患有溃疡性结肠炎或克罗恩病的家庭进行了免疫球蛋白重链和轻链同种异型研究，以寻找假定的疾病易感基因座与免疫球蛋白同种异型基因座之间的关联和/或连锁关系。未发现与特定免疫球蛋白同种异型存在关联或连锁的证据。