Biemond I, de Lange G G, Weterman I T, Pena A S
Gut. 1987 May;28(5):610-2. doi: 10.1136/gut.28.5.610.
An association between Crohn's disease and immunoglobulin allotypes has been reported. Confirmation of this association in other populations would be of particular importance for the study of hereditary factors in Crohn's disease. In the present study we have typed 155 unrelated Dutch patients with Crohn's disease and 450 blood donors for the Gm, Am, and Km markers. No significant differences were found in Gm phenotypes and haplotypes between patients and controls. It therefore seems unlikely that the immunoglobulin allotypes play an important role in the susceptibility of individuals to Crohn's disease.
已有报道称克罗恩病与免疫球蛋白同种异型之间存在关联。在其他人群中证实这种关联对于克罗恩病遗传因素的研究尤为重要。在本研究中，我们对155名无亲缘关系的荷兰克罗恩病患者和450名献血者进行了Gm、Am和Km标记分型。患者和对照组之间在Gm表型和单倍型上未发现显著差异。因此，免疫球蛋白同种异型似乎不太可能在个体对克罗恩病的易感性中起重要作用。
