Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Neurology, Minkodo Minohara Hospital, Fukuoka, Japan.
Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Neurosci Lett. 2019 Oct 15;711:134402. doi: 10.1016/j.neulet.2019.134402. Epub 2019 Jul 26.
Motion perceptual deficits are common in Alzheimer's disease (AD). Although the posterior parietal cortex is thought to play a critical role in these deficits, it is currently unclear whether the primary visual cortex (V1) contributes to these deficits in AD. To elucidate this issue, we investigated the net activity or connectivity within V1 in 17 amnestic mild cognitive impairment (aMCI) patients, 17 AD patients and 17 normal controls (NC) using functional magnetic resonance imaging (fMRI). fMRI was recorded under two conditions: visual motion stimulation and resting-state. The net activity or connectivity within V1 extracted by independent component analysis (ICA) was significantly increased during visual motion stimuli compared with that of the resting-state condition in NC, but not in aMCI or AD patients. These findings suggest the alteration of the net activity or connectivity within V1, which may contribute to the previously reported motion perceptual deficits in aMCI and AD. Therefore, the decreased net V1 activity measured as the strength of the ICA component may provide a new disease biomarker for early detection of AD.
运动知觉缺陷在阿尔茨海默病（AD）中很常见。尽管后顶叶皮层被认为在这些缺陷中起着关键作用，但目前尚不清楚初级视觉皮层（V1）是否会导致 AD 中的这些缺陷。为了阐明这个问题，我们使用功能磁共振成像（fMRI）研究了 17 名遗忘型轻度认知障碍（aMCI）患者、17 名 AD 患者和 17 名正常对照（NC）的 V1 内的净活动或连通性。fMRI 在两种条件下记录：视觉运动刺激和静息状态。与 NC 的静息状态相比，独立成分分析（ICA）提取的 V1 内的净活动或连通性在视觉运动刺激期间显著增加，但在 aMCI 或 AD 患者中没有增加。这些发现表明 V1 内的净活动或连通性发生了改变，这可能导致之前报道的 aMCI 和 AD 中的运动知觉缺陷。因此，作为 ICA 分量强度测量的 V1 活动的减少可能为 AD 的早期检测提供新的疾病生物标志物。
