从印度尼西亚食用油脂中制备单酰基甘油衍生物及其对金黄色葡萄球菌和大肠杆菌的抗菌活性测定。
Preparation of Monoacylglycerol Derivatives from Indonesian Edible Oil and Their Antimicrobial Assay against Staphylococcus aureus and Escherichia coli.
机构信息
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia.
Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, 501-1112, Japan.
出版信息
Sci Rep. 2019 Jul 29;9(1):10941. doi: 10.1038/s41598-019-47373-4.
In the present work, linoleic acid and oleic acid were isolated from Indonesian corn oil and palm oil and they were used to prepare monoacylglycerol derivatives as the antibacterial agent. Indonesian corn oil contains 57.74% linoleic acid, 19.88% palmitic acid, 11.84% oleic acid and 3.02% stearic acid. While Indonesian palm oil contains 44.72% oleic acid, 39.28% palmitic acid, 4.56% stearic acid and 1.54% myristic acid. The oleic acid was purified by using Urea Inclusion Complex (UIC) method and its purity was significantly increased from 44.72% to 94.71%. Meanwhile, with the UIC method, the purity of ethyl linoleate was increased from 57.74% to 72.14%. 1-Monolinolein and 2-monoolein compounds were synthesized via two-step process from the isolated linoleic acid and oleic acid, respectively. The preliminary antibacterial assay shows that the 1-monolinolein did not give any antibacterial activity against Staphylococcus aureus and Escherichia coli, while 2-monoolein showed weak antibacterial activity against Staphylococcus aureus.
在本工作中，从印度尼西亚玉米油和棕榈油中分离出亚油酸和油酸，并将其用于制备单酰基甘油衍生物作为抗菌剂。印度尼西亚玉米油含有 57.74%的亚油酸、19.88%的棕榈酸、11.84%的油酸和 3.02%的硬脂酸。而印度尼西亚棕榈油含有 44.72%的油酸、39.28%的棕榈酸、4.56%的硬脂酸和 1.54%的肉豆蔻酸。油酸通过脲包合（UIC）方法进行纯化，其纯度从 44.72%显著提高到 94.71%。同时，通过 UIC 方法，亚油酸乙酯的纯度从 57.74%提高到 72.14%。从分离得到的亚油酸和油酸分别通过两步法合成了 1-单亚油酸甘油酯和 2-单油酸甘油酯化合物。初步的抗菌试验表明，1-单亚油酸甘油酯对金黄色葡萄球菌和大肠杆菌没有任何抗菌活性，而 2-单油酸甘油酯对金黄色葡萄球菌表现出较弱的抗菌活性。
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