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初榨椰子油对链脲佐菌素诱导的糖尿病大鼠的有益作用及其对肠道菌群组成的影响。

Beneficial Effect of Virgin Coconut Oil on Alloxan-Induced Diabetes and Microbiota Composition in Rats.

机构信息

University of Belgrade Faculty of Biology, Belgrade, Republic of Serbia.

University of Belgrade Faculty of Medicine, Belgrade, Republic of Serbia.

出版信息

Plant Foods Hum Nutr. 2018 Dec;73(4):295-301. doi: 10.1007/s11130-018-0689-7.

DOI:10.1007/s11130-018-0689-7
PMID:30168039
Abstract

The gut microbiota is composed of a diverse population of obligate and facultative anaerobic microorganisms which are shown to influence host metabolism and immune homeostasis. This study investigated the effects of virgin coconut oil on the weekly fasting glycaemia, daily food and water intake and weekly body mass gain over 16 weeks, as well as the changes in composition of gut microbiota in both non-diabetic and alloxan-induced diabetic rats. Although the intake of virgin coconut oil did not decrease the diabetes-induced hyperglycemia, it affected the secondary parameters, such as food and water intake and average body mass gain. Furthermore, its potential to positively affect the fecal microbiome was proved, since it significantly increased the abundance of probiotic bacteria, such as Lactobacillus, Allobaculum and Bifidobacterium species.

摘要

肠道微生物群由多种专性和兼性厌氧微生物组成,这些微生物被证明可以影响宿主的新陈代谢和免疫稳态。本研究调查了初榨椰子油对 16 周内每周禁食血糖、每日食物和水摄入量以及每周体重增加的影响,以及在非糖尿病和链脲佐菌素诱导的糖尿病大鼠中肠道微生物群组成的变化。尽管初榨椰子油的摄入并没有降低糖尿病引起的高血糖,但它影响了其他参数,如食物和水的摄入以及平均体重的增加。此外,它还能显著增加益生菌,如乳杆菌、Allobaculum 和双歧杆菌属的丰度,这证明了它对粪便微生物群有积极的影响。

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本文引用的文献

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2
Characterization of fecal fat composition and gut derived fecal microbiota in high-fat diet fed rats following intervention with chito-oligosaccharide and resistant starch complexes.高脂肪饮食喂养的大鼠经壳寡糖和抗性淀粉复合物干预后粪便脂肪成分和肠道来源粪便微生物群的特征。
Food Funct. 2017 Dec 13;8(12):4374-4383. doi: 10.1039/c7fo01244f.
3
Assessment of gut microbiota populations in lean and obese Zucker rats.
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Nutrients. 2023 Jul 28;15(15):3371. doi: 10.3390/nu15153371.
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Probiotic Formulations Containing Fixed and Essential Oils Ameliorates SIBO-Induced Gut Dysbiosis in Rats.含有固定油和精油的益生菌制剂可改善大鼠小肠细菌过度生长诱导的肠道菌群失调。
Pharmaceuticals (Basel). 2023 Jul 22;16(7):1041. doi: 10.3390/ph16071041.
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Coconut oil and medium-chain fatty acids attenuate high-fat diet-induced obesity in mice through increased thermogenesis by activating brown adipose tissue.椰子油和中链脂肪酸通过激活棕色脂肪组织增加产热,从而减轻高脂饮食诱导的小鼠肥胖。
Front Nutr. 2022 Oct 28;9:896021. doi: 10.3389/fnut.2022.896021. eCollection 2022.
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Int J Food Sci. 2022 Jan 7;2022:3336941. doi: 10.1155/2022/3336941. eCollection 2022.
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