Shahriari Shahriar, Barekatain Mehrdad, Shahtalebi Mohammad Ali, Farhad Shirin Zahra
Department of Operative Dentistry, Faculty of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Department of Pharmaceutics, School of Pharmacy, Isfahan University of Medical Sciences and Health Services, Isfahan, Iran.
Int J Prev Med. 2019 Jun 12;10:110. doi: 10.4103/ijpvm.IJPVM_81_17. eCollection 2019.
In this study, the anti- and anti- properties of a restorative glass-ionomer cement (GIC) modified with extract powder of as a safe and effective herbal extract at weight concentration levels of 0.5%, 0.75%, 1%, and 1.25% are investigated.
The extract powder is provided by doing a multistep laboratory procedure and is filtered to obtain particles smaller than 50 μ. The GIC powder is modified by adding extract powder in weight concentrations of 0.5% (Group II), 0.75% (Group III), 1% (Group IV), and 1.25% (Group V) to form experimental groups, each of 1 g. Five disk-shaped samples, 1 cm in diameter and 2 mm height, of each group (including control group [Group I]) are prepared for each bacterial category of and . The twenty-five samples for each category are tested against strains of and . Following Agar diffusion tests, the inhibition zone diameters are recorded. The data are tested for normality by means of Kolmogorov-Smirnov procedure. The Kruskal-Wallis and Mann-Whitney tests are used to perform a one-way ANOVA and to do pair-wise comparisons, respectively, at 5% significance level.
The mean diameter of the inhibition zones are significantly different among the test groups and also the test groups and the control group except for the group with 0.5% in category which shows no significant difference with the control group.
The present study revealed direct inhibitory activities of -containing GIC against and in a dose-response manner.
在本研究中，研究了一种用[植物名称]提取物粉末改性的修复性玻璃离子水门汀（GIC）在0.5%、0.75%、1%和1.25%重量浓度水平下作为一种安全有效的草药提取物的抗菌和抗[具体细菌名称]特性。
通过多步骤实验室程序提供[植物名称]提取物粉末，并过滤以获得小于50μm的颗粒。通过添加重量浓度为0.5%（II组）、0.75%（III组）、1%（IV组）和1.25%（V组）的提取物粉末来改性GIC粉末，以形成实验组，每组1g。针对[具体细菌名称1]和[具体细菌名称2]的每种细菌类别，为每组（包括对照组[I组]）制备五个直径1cm、高2mm的盘状样品。对每种细菌类别的25个样品进行针对[具体细菌名称1]和[具体细菌名称2]菌株的测试。在琼脂扩散试验后，记录抑菌圈直径。通过Kolmogorov-Smirnov程序对数据进行正态性检验。分别使用Kruskal-Wallis检验和Mann-Whitney检验在5%显著性水平下进行单因素方差分析和两两比较。
除了在[具体细菌名称1]类别中0.5%组与对照组无显著差异外，测试组之间以及测试组与对照组之间的抑菌圈平均直径存在显著差异。
本研究揭示了含[植物名称]的GIC对[具体细菌名称1]和[具体细菌名称2]具有剂量反应方式的直接抑制活性。
