Shah Saiqa, Kalal Bhuvanesh Sukhlal
Yenepoya (Deemed to be University), Yenepoya Medical College, Department of Biochemistry, Mangaluru, India.
Vydehi Institute of Medical Sciences and Research Centre, Department of Biochemistry, Bengaluru, India.
Turk J Obstet Gynecol. 2019 Jun;16(2):124-128. doi: 10.4274/tjod.galenos.2019.19577. Epub 2019 Jul 3.
Cervical cancer (CaCx) is one of the leading causes of cancer-related death among women worldwide, with the great social and economic burden. Diagnoses in early stages can decrease mortality and morbidity rates. This study was conducted to evaluate the status of serum total antioxidant capacity (TAC), and malondialdehyde (MDA) and copper concentrations among patients with CaCx to determine the level of oxidative stress and effect on which of chemoradiation.
Fifty patients with histopathologically proven CaCx who visited the department of oncology & gynaecology and 50 age-matched healthy females were selected for the study. Serum TAC, MDA, and copper were estimated in both study groups. The effect of chemoradiation on these was estimated in patients with CaCx.
The mean ± standard deviation age of the patients was 43.98±6.38 years, whereas that of the controls was 31.56±6.84 years. The mean serum copper and MDA concentrations in the patients was significantly higher as compared with the controls, whereas the mean TAC in the patients was reduced when compared with the controls. After chemoradiation, there was a significant increase and decrease in TAC and MDA, respectively, after chemoradiotherapy, whereas the changes in the copper concentrations were insignificant.
These results suggest that patients with CaCx were in oxidative stress because the oxidative parameters in serum (copper, MDA) were increased and the defensive TAC was decreased in patients with CaCx and chemoradiotherapy improved their anti-oxidant capacity. Further studies are needed to evaluate the concurrent use of antioxidants with chemoradiotherapy for improving the disease prognosis.
宫颈癌（CaCx）是全球女性癌症相关死亡的主要原因之一，带来巨大的社会和经济负担。早期诊断可降低死亡率和发病率。本研究旨在评估CaCx患者血清总抗氧化能力（TAC）、丙二醛（MDA）和铜浓度的状况，以确定氧化应激水平及其对放化疗的影响。
选取50例经组织病理学证实的CaCx患者，这些患者就诊于肿瘤与妇科科室，同时选取50例年龄匹配的健康女性作为对照进行研究。对两个研究组均检测血清TAC、MDA和铜含量。评估放化疗对CaCx患者这些指标的影响。
患者的平均年龄为43.98±6.38岁，而对照组为31.56±6.84岁。患者血清铜和MDA的平均浓度显著高于对照组，而患者的平均TAC低于对照组。放化疗后，TAC显著升高，MDA显著降低，而铜浓度变化不显著。
这些结果表明CaCx患者处于氧化应激状态，因为血清中的氧化参数（铜、MDA）升高，而防御性TAC降低，放化疗提高了患者的抗氧化能力。需要进一步研究评估抗氧化剂与放化疗联合使用对改善疾病预后的作用。
