Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Curr Opin Chem Biol. 2021 Aug;63:78-85. doi: 10.1016/j.cbpa.2021.01.014. Epub 2021 Mar 15.
Nanomedicine research is an active field that produces thousands of studies every year. However, translation of nanotherapeutics to the clinic has yet to catch up with such a vast output. In recent years, the need to better understand nanomedicines' in vivo behavior has been identified as one of the major challenges for efficient clinical translation. In this context, noninvasive imaging offers attractive solutions to provide valuable information about nanomedicine biodistribution, pharmacokinetics, stability, or therapeutic efficacy. Here, we review the latest imaging approaches used in the development of therapeutic nanomedicines, discuss why these strategies bring added value along the translational pipeline, and give a perspective on future advances in the field.
纳米医学研究是一个活跃的领域，每年都会产生数千项研究。然而，纳米疗法向临床的转化尚未跟上如此庞大的产出。近年来，人们认识到，更好地了解纳米药物在体内的行为是提高临床转化效率的主要挑战之一。在这种情况下，无创成像提供了有吸引力的解决方案，可以提供有关纳米药物生物分布、药代动力学、稳定性或治疗效果的有价值的信息。在这里，我们回顾了在治疗性纳米药物开发中使用的最新成像方法，讨论了这些策略为何沿着转化途径带来附加值，并对该领域的未来进展进行了展望。
