Department of Statistics, Dongguk University, Seoul, South Korea.
Department of Family Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea.
Public Health. 2019 Oct;175:1-3. doi: 10.1016/j.puhe.2019.06.012. Epub 2019 Jul 27.
The aim of the study is to examine associations between paternal age at childbirth and offspring cardiovascular risk factors in adolescence.
This is a cross-sectional study.
Data from the 2007-2016 Korea National Health and Nutrition Examination Survey was used. A total of 4,096 adolescents were included in the final analysis, and their information on blood pressure, fasting glucose level, and lipid profile was collected. Multiple linear regression models were applied to evaluate the effect of paternal age on cardiovascular risk factors with adjustment for potential confounders.
The median age of participants was 13 years, and 53.2% were male. Maternal and paternal ages were closely correlated with each other, and older parents had older offspring. Paternal age was positively associated with levels of total cholesterol (p = 0.033) and triglycerides (p = 0.042) after adjusting for confounders.
This nationwide study shows that advanced paternal age is associated with a less favorable lipid profile in a dose-dependent manner.
本研究旨在探讨父亲生育时的年龄与青少年后代心血管风险因素之间的关联。
这是一项横断面研究。
本研究使用了 2007-2016 年韩国国家健康和营养检查调查的数据。最终分析共纳入了 4096 名青少年，收集了他们的血压、空腹血糖水平和血脂谱信息。采用多元线性回归模型，在调整潜在混杂因素后，评估父亲年龄对心血管风险因素的影响。
参与者的中位年龄为 13 岁，其中 53.2%为男性。母亲和父亲的年龄彼此密切相关，年长的父母有更年长的后代。在调整混杂因素后，父亲年龄与总胆固醇（p=0.033）和甘油三酯（p=0.042）水平呈正相关。
这项全国性研究表明，父亲年龄的增加与血脂谱的不利变化呈剂量依赖性相关。
