Javed Ayesha, Ravi Phanish C, Bilal Delvi Sarah, Faraz Hussain Iqra, Acosta G Arnaldo J, Iqbal Warda, Krishnamaneni Vamsi, Alasaadi Saya, Pradhan Swetapadma, Vashisht Rishabh, Modi Shivani
Gynecology, Heart's International Hospital, Rawalpindi, PAK.
Medicine and Surgery, Sri Venkata Sai Medical College, Telangana, IND.
Cureus. 2023 Sep 28;15(9):e46134. doi: 10.7759/cureus.46134. eCollection 2023 Sep.
This thorough literature evaluation was prompted by significant research into the complex interactions between estrogen use and myocardial infarction (MI). Estrogen has fascinated researchers because of its possible cardioprotective benefits and its impact on cardiovascular health. In order to clarify the connection between estrogen use and the risk of MI, this review critically examines the body of prior evidence. This review focuses on estrogen and its pivotal role in cardiovascular health, concentrating on lipid metabolism, vasodilation, inflammation, and endothelial function. It examines contentious data about estrogen therapy's heart-protective effects, taking into account age, initiation timing, dosage, and dosage of administration. Genetic and epigenetic influences on MI risk among estrogen users highlight intricate, personalized estrogen effects. The conclusion summarizes the main findings and emphasizes the need for an all-encompassing strategy for initiating and managing estrogen medication. It is crucial to consider patient-specific traits and risk factors to successfully customize treatment regimens. This review sheds vital light on the potential directions for better cardiovascular treatment for postmenopausal women by shedding light on the complex link between estrogen use and myocardial infarction. The review also identifies research gaps and future objectives in this area, highlighting the demand for novel medicines and individualized strategies to improve cardiovascular outcomes.
对雌激素使用与心肌梗死（MI）之间复杂相互作用的大量研究促使了此次全面的文献评估。雌激素因其可能的心脏保护益处及其对心血管健康的影响而吸引了研究人员。为了阐明雌激素使用与心肌梗死风险之间的联系，本综述批判性地审视了先前的证据。本综述聚焦于雌激素及其在心血管健康中的关键作用，重点关注脂质代谢、血管舒张、炎症和内皮功能。它审视了关于雌激素疗法心脏保护作用的有争议的数据，同时考虑了年龄、起始时间、剂量和给药方式。雌激素使用者中基因和表观遗传对心肌梗死风险的影响凸显了雌激素复杂的个性化作用。结论总结了主要发现，并强调了启动和管理雌激素药物治疗需要全面策略。考虑患者特定特征和风险因素对于成功定制治疗方案至关重要。本综述通过阐明雌激素使用与心肌梗死之间的复杂联系，为绝经后女性更好的心血管治疗潜在方向提供了重要启示。该综述还确定了该领域的研究空白和未来目标，强调了对新型药物和个性化策略的需求，以改善心血管结局。
