既往登革病毒感染与登革热感染患者病毒载量增加相关，但与寨卡病毒感染患者无关。
Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus.
作者信息
Santiago Gilberto A, Sharp Tyler M, Rosenberg Eli, Sosa Cardona Iris I, Alvarado Luisa, Paz-Bailey Gabriela, Muñoz-Jordán Jorge L
机构信息
Centers for Disease Control and Prevention, Dengue Branch, San Juan, Puerto Rico.
United States Public Health Service, Silver Springs, Maryland.
出版信息
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz320.
Abstract
To evaluate potential enhancement of Zika virus (ZIKV) infection among patients with prior dengue virus (DENV) infection, we compared loads of viral RNA among patients infected with ZIKV (n = 1070), DENV-2 (n = 312), or DENV-3 (n = 260). Compared to patients without prior DENV infection, patients with prior DENV infection had significantly higher mean loads of viral RNA if infected with DENV-2 (10.6 vs 11.6 log10 GCE/mL, respectively; t test, P < .0001) or DENV-3 (10.3 vs 10.9 log10 GCE/mL; P < .0001), but not ZIKV (4.7 vs 4.7 log10 GCE/mL; P = .959). These findings provide evidence against in vivo enhancement of ZIKV by anti-DENV antibodies.
摘要
为评估既往感染登革病毒（DENV）的患者中寨卡病毒（ZIKV）感染的潜在增强情况，我们比较了感染ZIKV（n = 1070）、DENV-2（n = 312）或DENV-3（n = 260）的患者的病毒RNA载量。与无既往DENV感染的患者相比，既往感染DENV的患者若感染DENV-2（分别为10.6对11.6 log10 GCE/mL；t检验，P <.0001）或DENV-3（10.3对10.9 log10 GCE/mL；P <.0001），其病毒RNA平均载量显著更高，但感染ZIKV时并非如此（4.7对4.7 log10 GCE/mL；P =.959）。这些发现提供了抗DENV抗体不会在体内增强ZIKV感染的证据。
相似文献
1
Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus.既往登革病毒感染与登革热感染患者病毒载量增加相关，但与寨卡病毒感染患者无关。
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz320.
2
Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus-Infected Patients.病毒载量和细胞因子反应谱不支持登革热病毒感染的 Zika 病毒患者的抗体依赖性增强。
Clin Infect Dis. 2017 Oct 15;65(8):1260-1265. doi: 10.1093/cid/cix558.
3
Modulation of Dengue/Zika Virus Pathogenicity by Antibody-Dependent Enhancement and Strategies to Protect Against Enhancement in Zika Virus Infection.抗体依赖性增强作用对登革热/寨卡病毒致病性的调节作用及寨卡病毒感染中预防增强作用的策略。
Front Immunol. 2018 Apr 23;9:597. doi: 10.3389/fimmu.2018.00597. eCollection 2018.
4
Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus.登革热病毒衣壳和 NS3 特异性记忆 T 细胞对 Zika 病毒的交叉反应性和抗病毒功能。
Front Immunol. 2018 Oct 1;9:2225. doi: 10.3389/fimmu.2018.02225. eCollection 2018.
5
Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection. Zika 恢复期猕猴在登革热感染后表现出迟发性回忆性中和抗体反应的诱导。
Emerg Microbes Infect. 2018 Jul 13;7(1):130. doi: 10.1038/s41426-018-0132-z.
6
Improved Immune Responses Against Zika Virus After Sequential Dengue and Zika Virus Infection in Humans.人类在先后感染登革热病毒和 Zika 病毒后，对 Zika 病毒产生了增强的免疫应答。
Viruses. 2018 Sep 7;10(9):480. doi: 10.3390/v10090480.
7
Does prior dengue virus exposure worsen clinical outcomes of Zika virus infection? A systematic review, pooled analysis and lessons learned.既往登革病毒感染是否会加重寨卡病毒感染的临床结局？系统评价、汇总分析及经验教训。
PLoS Negl Trop Dis. 2019 Jan 25;13(1):e0007060. doi: 10.1371/journal.pntd.0007060. eCollection 2019 Jan.
8
Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaques.登革热或 Zika 病毒的初次感染不会影响猕猴中异源二次感染的严重程度。
PLoS Pathog. 2019 Aug 1;15(8):e1007766. doi: 10.1371/journal.ppat.1007766. eCollection 2019 Aug.
9
Dengue and Zika Virus Domain III-Flagellin Fusion and Glycan-Masking E Antigen for Prime-Boost Immunization.登革热和 Zika 病毒结构域 III-鞭毛蛋白融合和糖基掩蔽 E 抗原用于初次-加强免疫。
Theranostics. 2019 Jul 9;9(16):4811-4826. doi: 10.7150/thno.35919. eCollection 2019.
10
Cross-reactive Dengue virus-specific CD8 T cells protect against Zika virus during pregnancy.交叉反应性登革热病毒特异性 CD8 T 细胞可在怀孕期间预防寨卡病毒。
Nat Commun. 2018 Aug 2;9(1):3042. doi: 10.1038/s41467-018-05458-0.
引用本文的文献
1
Technical validation of a multiplex real-time PCR for combined detection of Rift Valley fever, chikungunya, Zika and dengue viruses.用于联合检测裂谷热、基孔肯雅热、寨卡病毒和登革热病毒的多重实时聚合酶链反应的技术验证
J Virol Methods. 2025 Sep;337:115174. doi: 10.1016/j.jviromet.2025.115174. Epub 2025 May 7.
2
Mouse models of Zika virus transplacental transmission.寨卡病毒经胎盘传播的小鼠模型。
Antiviral Res. 2023 Feb;210:105500. doi: 10.1016/j.antiviral.2022.105500. Epub 2022 Dec 22.
3
Vector competence of lambda-cyhalothrin resistant Aedes aegypti strains for dengue-2, Zika and chikungunya viruses in Colombia.哥伦比亚具有抗 lambda-氯氰菊酯抗性的埃及伊蚊品系对登革热 2 型、寨卡和基孔肯雅热病毒的媒介效能。
PLoS One. 2022 Oct 25;17(10):e0276493. doi: 10.1371/journal.pone.0276493. eCollection 2022.
4
Short-term and long-term epidemiological impacts of sustained vector control in various dengue endemic settings: A modelling study.在不同登革热流行地区持续进行病媒控制的短期和长期流行病学影响：一项建模研究。
PLoS Comput Biol. 2022 Apr 1;18(4):e1009979. doi: 10.1371/journal.pcbi.1009979. eCollection 2022 Apr.
5
Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques.先前暴露于登革热病毒会导致恒河猴母胎界面的寨卡病毒载量增加。
PLoS Negl Trop Dis. 2021 Jul 30;15(7):e0009641. doi: 10.1371/journal.pntd.0009641. eCollection 2021 Jul.
6
Knowledge gaps in the epidemiology of severe dengue impede vaccine evaluation.严重登革热流行病学知识空白阻碍疫苗评估。
Lancet Infect Dis. 2022 Feb;22(2):e42-e51. doi: 10.1016/S1473-3099(20)30871-9. Epub 2021 Jul 12.
7
Congenital abnormalities associated with Zika virus infection-Dengue as potential co-factor? A systematic review.先天性异常与寨卡病毒感染相关 - 登革热是否为潜在的共同因素？系统评价。
PLoS Negl Trop Dis. 2021 Jan 4;15(1):e0008984. doi: 10.1371/journal.pntd.0008984. eCollection 2021 Jan.
8
Protective and enhancing interactions among dengue viruses 1-4 and Zika virus.登革热病毒 1-4 型与寨卡病毒之间的保护和增强相互作用。
Curr Opin Virol. 2020 Aug;43:59-70. doi: 10.1016/j.coviro.2020.08.006. Epub 2020 Sep 24.
9
Presence of Flavivirus Antibodies Does Not Lead to a Greater Number of Symptoms in a Small Cohort of Canadian Travelers Infected with Zika Virus.在一小部分感染寨卡病毒的加拿大旅行者中，黄病毒抗体的存在并不会导致更多症状。
Viruses. 2020 Jan 24;12(2):140. doi: 10.3390/v12020140.
本文引用的文献
1
Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil.巴西东北部登革热病毒感染对先天性寨卡综合征的交叉保护作用。
Emerg Infect Dis. 2019 Aug;25(8):1485-1493. doi: 10.3201/eid2508.190113. Epub 2019 Aug 17.
2
Dengue.登革热。
Lancet. 2019 Jan 26;393(10169):350-363. doi: 10.1016/S0140-6736(18)32560-1.
3
The emergence of Zika virus and its new clinical syndromes.寨卡病毒的出现及其新的临床综合征。
Nature. 2018 Aug;560(7720):573-581. doi: 10.1038/s41586-018-0446-y. Epub 2018 Aug 29.
4
Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome.增强型寨卡和登革热中和抗体与吉兰-巴雷综合征相关。
J Infect Dis. 2019 Jan 1;219(1):26-30. doi: 10.1093/infdis/jiy466.
5
Performance of the Trioplex real-time RT-PCR assay for detection of Zika, dengue, and chikungunya viruses.三重实时 RT-PCR 检测 Zika、登革热和基孔肯雅热病毒的性能。
Nat Commun. 2018 Apr 11;9(1):1391. doi: 10.1038/s41467-018-03772-1.
6
A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?两种病毒的故事：异源黄病毒免疫会增强寨卡病吗？
Trends Microbiol. 2018 Mar;26(3):186-190. doi: 10.1016/j.tim.2017.10.004. Epub 2017 Nov 6.
7
Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus-Infected Patients.病毒载量和细胞因子反应谱不支持登革热病毒感染的 Zika 病毒患者的抗体依赖性增强。
Clin Infect Dis. 2017 Oct 15;65(8):1260-1265. doi: 10.1093/cid/cix558.
8
Clinical and epidemiologic characteristics of dengue and other etiologic agents among patients with acute febrile illness, Puerto Rico, 2012-2015.2012 - 2015年波多黎各急性发热疾病患者中登革热及其他病原体的临床和流行病学特征
PLoS Negl Trop Dis. 2017 Sep 13;11(9):e0005859. doi: 10.1371/journal.pntd.0005859. eCollection 2017 Sep.
9
Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus.寨卡病毒在恒河猴中的发病机制不受预先存在的登革热病毒免疫的影响。
Nat Commun. 2017 Jun 23;8:15674. doi: 10.1038/ncomms15674.
10
Maternal Zika Virus Disease Severity, Virus Load, Prior Dengue Antibodies, and Their Relationship to Birth Outcomes.孕妇寨卡病毒病的严重程度、病毒载量、既往登革热抗体及其与分娩结局的关系。
Clin Infect Dis. 2017 Sep 15;65(6):877-883. doi: 10.1093/cid/cix472.
Zotero 插件