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本文引用的文献

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Cross-Protection of Dengue Virus Infection against Congenital Zika Syndrome, Northeastern Brazil.巴西东北部登革热病毒感染对先天性寨卡综合征的交叉保护作用。
Emerg Infect Dis. 2019 Aug;25(8):1485-1493. doi: 10.3201/eid2508.190113. Epub 2019 Aug 17.
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Dengue.登革热。
Lancet. 2019 Jan 26;393(10169):350-363. doi: 10.1016/S0140-6736(18)32560-1.
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The emergence of Zika virus and its new clinical syndromes.寨卡病毒的出现及其新的临床综合征。
Nature. 2018 Aug;560(7720):573-581. doi: 10.1038/s41586-018-0446-y. Epub 2018 Aug 29.
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Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barré Syndrome.增强型寨卡和登革热中和抗体与吉兰-巴雷综合征相关。
J Infect Dis. 2019 Jan 1;219(1):26-30. doi: 10.1093/infdis/jiy466.
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Performance of the Trioplex real-time RT-PCR assay for detection of Zika, dengue, and chikungunya viruses.三重实时 RT-PCR 检测 Zika、登革热和基孔肯雅热病毒的性能。
Nat Commun. 2018 Apr 11;9(1):1391. doi: 10.1038/s41467-018-03772-1.
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A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease?两种病毒的故事：异源黄病毒免疫会增强寨卡病吗？
Trends Microbiol. 2018 Mar;26(3):186-190. doi: 10.1016/j.tim.2017.10.004. Epub 2017 Nov 6.
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Viral Load and Cytokine Response Profile Does Not Support Antibody-Dependent Enhancement in Dengue-Primed Zika Virus-Infected Patients.病毒载量和细胞因子反应谱不支持登革热病毒感染的 Zika 病毒患者的抗体依赖性增强。
Clin Infect Dis. 2017 Oct 15;65(8):1260-1265. doi: 10.1093/cid/cix558.
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Clinical and epidemiologic characteristics of dengue and other etiologic agents among patients with acute febrile illness, Puerto Rico, 2012-2015.2012 - 2015年波多黎各急性发热疾病患者中登革热及其他病原体的临床和流行病学特征
PLoS Negl Trop Dis. 2017 Sep 13;11(9):e0005859. doi: 10.1371/journal.pntd.0005859. eCollection 2017 Sep.
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Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus.寨卡病毒在恒河猴中的发病机制不受预先存在的登革热病毒免疫的影响。
Nat Commun. 2017 Jun 23;8:15674. doi: 10.1038/ncomms15674.
10
Maternal Zika Virus Disease Severity, Virus Load, Prior Dengue Antibodies, and Their Relationship to Birth Outcomes.孕妇寨卡病毒病的严重程度、病毒载量、既往登革热抗体及其与分娩结局的关系。
Clin Infect Dis. 2017 Sep 15;65(6):877-883. doi: 10.1093/cid/cix472.

既往登革病毒感染与登革热感染患者病毒载量增加相关，但与寨卡病毒感染患者无关。

Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus.

作者信息

Santiago Gilberto A, Sharp Tyler M, Rosenberg Eli, Sosa Cardona Iris I, Alvarado Luisa, Paz-Bailey Gabriela, Muñoz-Jordán Jorge L

机构信息

Centers for Disease Control and Prevention, Dengue Branch, San Juan, Puerto Rico.

United States Public Health Service, Silver Springs, Maryland.

出版信息

Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz320.

DOI:10.1093/ofid/ofz320
PMID:31363765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6667713/
Abstract

To evaluate potential enhancement of Zika virus (ZIKV) infection among patients with prior dengue virus (DENV) infection, we compared loads of viral RNA among patients infected with ZIKV (n = 1070), DENV-2 (n = 312), or DENV-3 (n = 260). Compared to patients without prior DENV infection, patients with prior DENV infection had significantly higher mean loads of viral RNA if infected with DENV-2 (10.6 vs 11.6 log10 GCE/mL, respectively; t test, P < .0001) or DENV-3 (10.3 vs 10.9 log10 GCE/mL; P < .0001), but not ZIKV (4.7 vs 4.7 log10 GCE/mL; P = .959). These findings provide evidence against in vivo enhancement of ZIKV by anti-DENV antibodies.

摘要

为评估既往感染登革病毒（DENV）的患者中寨卡病毒（ZIKV）感染的潜在增强情况，我们比较了感染ZIKV（n = 1070）、DENV-2（n = 312）或DENV-3（n = 260）的患者的病毒RNA载量。与无既往DENV感染的患者相比，既往感染DENV的患者若感染DENV-2（分别为10.6对11.6 log10 GCE/mL；t检验，P <.0001）或DENV-3（10.3对10.9 log10 GCE/mL；P <.0001），其病毒RNA平均载量显著更高，但感染ZIKV时并非如此（4.7对4.7 log10 GCE/mL；P =.959）。这些发现提供了抗DENV抗体不会在体内增强ZIKV感染的证据。