既往登革病毒感染与登革热感染患者病毒载量增加相关，但与寨卡病毒感染患者无关。
Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus.
作者信息
Santiago Gilberto A, Sharp Tyler M, Rosenberg Eli, Sosa Cardona Iris I, Alvarado Luisa, Paz-Bailey Gabriela, Muñoz-Jordán Jorge L
机构信息
Centers for Disease Control and Prevention, Dengue Branch, San Juan, Puerto Rico.
United States Public Health Service, Silver Springs, Maryland.
出版信息
Open Forum Infect Dis. 2019 Jul 1;6(7). doi: 10.1093/ofid/ofz320.
Abstract
To evaluate potential enhancement of Zika virus (ZIKV) infection among patients with prior dengue virus (DENV) infection, we compared loads of viral RNA among patients infected with ZIKV (n = 1070), DENV-2 (n = 312), or DENV-3 (n = 260). Compared to patients without prior DENV infection, patients with prior DENV infection had significantly higher mean loads of viral RNA if infected with DENV-2 (10.6 vs 11.6 log10 GCE/mL, respectively; t test, P < .0001) or DENV-3 (10.3 vs 10.9 log10 GCE/mL; P < .0001), but not ZIKV (4.7 vs 4.7 log10 GCE/mL; P = .959). These findings provide evidence against in vivo enhancement of ZIKV by anti-DENV antibodies.
摘要
为评估既往感染登革病毒（DENV）的患者中寨卡病毒（ZIKV）感染的潜在增强情况，我们比较了感染ZIKV（n = 1070）、DENV-2（n = 312）或DENV-3（n = 260）的患者的病毒RNA载量。与无既往DENV感染的患者相比，既往感染DENV的患者若感染DENV-2（分别为10.6对11.6 log10 GCE/mL；t检验，P <.0001）或DENV-3（10.3对10.9 log10 GCE/mL；P <.0001），其病毒RNA平均载量显著更高，但感染ZIKV时并非如此（4.7对4.7 log10 GCE/mL；P =.959）。这些发现提供了抗DENV抗体不会在体内增强ZIKV感染的证据。
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