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寨卡病毒在恒河猴中的发病机制不受预先存在的登革热病毒免疫的影响。

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus.

机构信息

Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico 00952, USA.

Department of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico 00936, USA.

出版信息

Nat Commun. 2017 Jun 23;8:15674. doi: 10.1038/ncomms15674.

DOI:10.1038/ncomms15674
PMID:28643775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5490051/
Abstract

Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to naïve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.

摘要

Zika 病毒（ZIKV）是一种新出现的病毒，最近已传播到登革热病毒（DENV）流行地区，交叉反应性抗体（Abs）可能会影响 ZIKV 的发病机制。使用 DENV 免疫血清，已经在体外证明 ZIKV 感染的抗体依赖性增强（ADE）可能发生。在这里，我们研究了预先存在的 DENV 免疫对体内 ZIKV 感染的影响。我们用 ZIKV 感染两个恒河猴队列；一个队列在 2.8 年前接触过 DENV，第二个对照队列对黄病毒感染没有免疫力。我们的结果虽然证实了体外的 ADE，但表明预先存在的 DENV 免疫力不会导致更严重的 ZIKV 疾病。相反，我们的结果表明，与无经验的猕猴相比，ZIKV 病毒血症的天数减少，并且先前接触 DENV 可能导致免疫反应的调节，而不会导致 ZIKV 发病机制的增强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c4a/5490051/749020e5cc4b/ncomms15674-f8.jpg
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