Department of Epidemiology and Biostatistics Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan Districts, Hefei, 230032, Anhui, People's Republic of China.
Ma'anshan Center for Disease Control and Provention, Ma'anshan, Anhui, People's Republic of China.
Arch Environ Contam Toxicol. 2019 Nov;77(4):490-500. doi: 10.1007/s00244-019-00655-4. Epub 2019 Jul 30.
Metals from the natural environment have potential hypertension effects. However, relevant studies on this topic are few. A total of 1358 adults aged 18-74 years from Chizhou, Maanshan, and Tongling of Anhui Province participated in the baseline study from 2014 to 2015. The follow-up study was performed from 2016 to 2017. Inductively coupled plasma optical emission spectrometry (7000 DV) was used to measure urinary Cr, Mn, Fe, Cu, and Zn of residents. Urinary concentrations of Cd determined via TAS-900 atomic absorption spectrophotometry at 228.8 nm wavelength. A total of 275 hypertension cases were identified. After adjusting for sociodemographic factors and risk factors for hypertension, four metals (Cd, Cr, Cu, and Mn) were significantly associated with hypertension in the single-metal model. Upon including all metals in the same model, the hazard ratios of the highest quartiles Cd and Cu compared with the reference group were 1.42 (95% confidence interval [CI] 1.09-2.02) and 1.56 (95% CI 1.16-2.09) for cases of hypertension. Our findings suggested that high levels of Cd and Cu might increase the incidence of hypertension. Further studies involving larger population should be conducted to confirm these findings.
环境中的金属具有潜在的高血压效应。然而，关于这个主题的相关研究很少。本研究共纳入了来自安徽省池州、马鞍山和铜陵的 1358 名 18-74 岁成年人，他们参加了 2014 年至 2015 年的基线研究，并于 2016 年至 2017 年进行了随访研究。采用电感耦合等离子体发射光谱法（7000DV）测量居民尿铬、锰、铁、铜和锌的浓度。采用 TAS-900 原子吸收分光光度计（波长 228.8nm）测定尿镉浓度。共确定了 275 例高血压病例。在调整了社会人口因素和高血压危险因素后，在单金属模型中，四种金属（镉、铬、铜和锰）与高血压显著相关。在将所有金属纳入同一模型后，与参考组相比，镉和铜的最高四分位数的危险比分别为 1.42（95%置信区间[CI] 1.09-2.02）和 1.56（95%CI 1.16-2.09）。我们的研究结果表明，高水平的镉和铜可能会增加高血压的发病率。应进行涉及更大人群的进一步研究来证实这些发现。
