Salihoğlu Salih, Doğan Sevil Ceyhan, Kavakçı Önder
Department of Physical Medicine and Rehabilitation, Medicana Sivas Hospital, Sivas, Turkey.
Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey.
Eur J Rheumatol. 2018 Jul 1;6(3):126-129. doi: 10.5152/eurjrheum.2019.18184. Print 2019 Jul.
The etiology of rheumatic diseases is unclear, but it is thought that environmental factors added to immunogenetic mechanisms in chronic inflammatory diseases play a role. Many inflammatory disorders, autoimmune diseases, and painful conditions have been shown to be associated with the psychological trauma of childhood. The aim of the present study was to investigate childhood psychological trauma that is considered to be one of the environmental factors that initiate inflammation on patients with rheumatic diseases.
In our study, a total of 440 patients (220 patients who have rheumatic diseases as the case group and 220 patients who have no rheumatic disease as the control group) were examined. The Childhood Trauma Questionnaire-28 (CTQ-28) was administered and was completed by the patients. This was a cross-sectional study design.
No statistically significant differences were found between the case and control groups with respect to age, gender, marital status, and educational level. The CTQ-28 scale was found to be significantly higher in patients with rheumatic diseases (ankylosing spondylitis, rheumatoid arthritis, and connective tissue disease) in our study.
We think that childhood psychiatric traumas are effective in the etiopathogenesis of rheumatic diseases. To make this relationship more understandable, multidisciplinary research and long-term follow-up studies are needed to examine neuroendocrine, genetic, and epidemiological factors.
风湿性疾病的病因尚不清楚，但人们认为，环境因素加之慢性炎症性疾病中的免疫遗传机制发挥了作用。许多炎症性疾病、自身免疫性疾病和疼痛性疾病已被证明与童年时期的心理创伤有关。本研究的目的是调查童年心理创伤，其被认为是引发风湿性疾病患者炎症的环境因素之一。
在我们的研究中，共检查了440名患者（220名患有风湿性疾病的患者作为病例组，220名没有风湿性疾病的患者作为对照组）。采用儿童创伤问卷28项版（CTQ - 28）并由患者完成。这是一项横断面研究设计。
病例组和对照组在年龄、性别、婚姻状况和教育水平方面未发现统计学上的显著差异。在我们的研究中，发现CTQ - 28量表在患有风湿性疾病（强直性脊柱炎、类风湿性关节炎和结缔组织病）的患者中显著更高。
我们认为童年精神创伤在风湿性疾病的病因发病机制中起作用。为了使这种关系更易于理解，需要进行多学科研究和长期随访研究来检查神经内分泌、遗传和流行病学因素。
