Kadamkulam Syriac Arun, Bhaskarla Amrit Ved, Elrifai Mohamed, Alraiyes Abdul Hamid
Internal Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.
Cleveland Clinic, Cleveland, Ohio, USA.
BMJ Case Rep. 2019 Jul 30;12(7):e229779. doi: 10.1136/bcr-2019-229779.
Endobronchial metastasis (EBM) from extrapulmonary primary malignancy is a rare entity. Although the most common site of metastasis of osteosarcoma is the lungs, EBM remains a rare occurrence. Cough and dyspnea are the most common symptoms. A significant number of patients are asymptomatic, making the diagnosis without any radiographic imaging challenging. CT scan of the lung, along with bronchoscopy and biopsy, is the mainstay of diagnosis and staging. A 36-year-old man presented with small cell osteosarcoma of the left maxillary region and was treated with surgery and adjuvant chemotherapy. The patient presented 8 years later with axillary metastasis and was found to have lung metastasis on further workup. Bronchoscopy and biopsy proved an EBM that was debulked by hot snare technique. The patient was then started on chemotherapy for recurrent small cell osteosarcoma.
肺外原发性恶性肿瘤的支气管内转移(EBM)是一种罕见的情况。虽然骨肉瘤最常见的转移部位是肺部,但EBM仍然很少见。咳嗽和呼吸困难是最常见的症状。相当一部分患者没有症状,这使得在没有任何影像学检查的情况下进行诊断具有挑战性。肺部CT扫描,连同支气管镜检查和活检,是诊断和分期的主要方法。一名36岁男性,表现为左上颌区域的小细胞骨肉瘤,接受了手术和辅助化疗。8年后,该患者出现腋窝转移,进一步检查发现有肺转移。支气管镜检查和活检证实为EBM,通过热圈套技术进行了减瘤治疗。然后该患者开始接受复发性小细胞骨肉瘤的化疗。