Yang Ai-Min, Hu Xiao-Bin, Liu Simin, Cheng Ning, Zhang De-Sheng, Li Juan-Sheng, Li Hai-Yan, Ren Xiao-Wei, Li Na, Sheng Xi-Pin, Ding Jiao, Zheng Shan, Wang Min-Zheng, Zheng Tong-Zhang, Bai Ya-Na
Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, China.
Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02912, USA.
Chronic Dis Transl Med. 2019 Jun 26;5(2):97-104. doi: 10.1016/j.cdtm.2019.05.002. eCollection 2019 Jun.
Both exposure to heavy metals and alcohol intake have been related to the risk of type 2 diabetes (T2D). In this study, we aimed to assess the potential interactions between metal exposure and alcohol intake on the risk of T2D and prediabetes in a cohort of Chinese male workers.
We conducted a cross-sectional analysis of 26,008 Chinese male workers in an occupational cohort study from 2011 to 2013. We assessed metal exposure and alcohol consumption at baseline in these workers who were aged ≥20 years. Based on occupations which were categorized according to measured urine metal levels, multiple logistic regression analyses were used to evaluate the independent and joint effects of metal and alcohol exposure on the risk of T2D and prediabetes.
Risks of T2D ( = 0.001) and prediabetes ( = 0.001) were significantly elevated with increasing number of standard drinks per week, years of drinking, and lifetime alcohol consumption. An adjusted odds ratio () of 6.1 (95% confidence interval []: 4.8-7.8) was observed for the smelting/refining workers (highest metal exposure levels) who had the highest lifetime alcohol consumption (>873 kg) ( = 0.018), whereas no statistically significant joint effect was found for prediabetes ( = 0.515).
Both exposures to metal and heavy alcohol intake were associated with the risk of diabetes in this large cohort of male workers. There was a strong interaction between these two exposures in affecting diabetes risk that needs to be confirmed in future studies.
接触重金属和饮酒均与2型糖尿病（T2D）风险相关。在本研究中，我们旨在评估中国男性工人队列中金属暴露与饮酒对T2D和糖尿病前期风险的潜在相互作用。
我们对2011年至2013年职业队列研究中的26008名中国男性工人进行了横断面分析。我们在这些年龄≥20岁的工人基线时评估了金属暴露和饮酒情况。根据根据测量的尿金属水平分类的职业，采用多元逻辑回归分析来评估金属和酒精暴露对T2D和糖尿病前期风险的独立和联合作用。
每周标准饮酒量增加、饮酒年限和终生酒精摄入量增加，T2D（P = 0.001）和糖尿病前期（P = 0.001）风险显著升高。对于终生酒精摄入量最高（>873千克）的冶炼/精炼工人（金属暴露水平最高），观察到调整后的优势比（OR）为6.1（95%置信区间[CI]：4.8 - 7.8）（P = 0.018），而糖尿病前期未发现统计学上显著的联合作用（P = 0.515）。
在这个大型男性工人队列中，金属暴露和大量饮酒均与糖尿病风险相关。这两种暴露在影响糖尿病风险方面存在强烈的相互作用，需要在未来研究中加以证实。
