Yang Ai Min, Cheng Ning, Pu Hong Quan, Liu Si Min, Li Juan Sheng, Bassig Bryan A, Dai Min, Li Hai Yan, Hu Xiao Bin, Ren Xiao Wei, Zheng Tong Zhang, Bai Ya Na
Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, Gansu, China; Department of Epidemiology, School of Public Health, Brown University, Providence, RI 02912, USA.
Center of Medical Laboratory, Lanzhou University, Lanzhou 730000, Gansu, China.
Biomed Environ Sci. 2015 Dec;28(12):875-83. doi: 10.3967/bes2015.121.
To study the association between metal exposure and risk of diabetes and prediabetes among Chinese workers exposed to metals.
We used data obtained from the baseline survey of the Jinchang Cohort Study of workers in Jinchang Industry, the largest nickel production company in China. A total of 42,122 workers ⋝20 years of age were included in the study. A standardized, structured questionnaire was used to collect epidemiological information. Physical examinations and laboratory tests were conducted to evaluate the health status of the participants and to measure various biomarkers including blood sugar, lipids, and urinary metal concentrations. Logistic regression was used to study the association between occupational groups categorized according to the measured metal levels (office workers, low-level; mining/production workers, mid-level; and smelting/refining workers, high-level) and risk of diabetes and prediabetes.
The overall prevalence of diabetes and prediabetes was 7.5% and 16.8%, respectively. The adjusted odds ratios for diabetes among mining/production workers and smelting/refining workers compared to office workers were 1.5 (95% CI: 1.3, 1.7) and 3.8 (95% CI: 3.4, 4.3), respectively. No association was observed between these occupational groups and prediabetes in this study.
Occupations associated with higher levels of metal exposure were associated with an increased risk of diabetes in this cohort. More studies are needed to confirm this observed association.
研究中国金属暴露工人中金属暴露与糖尿病及糖尿病前期风险之间的关联。
我们使用了来自金昌队列研究基线调查的数据，该研究针对中国最大的镍生产公司金昌实业的工人。共有42122名年龄≥20岁的工人纳入研究。采用标准化的结构化问卷收集流行病学信息。进行体格检查和实验室检测以评估参与者的健康状况，并测量包括血糖、血脂和尿金属浓度在内的各种生物标志物。采用逻辑回归研究根据测量的金属水平分类的职业组（办公室工作人员，低暴露水平；采矿/生产工人，中等暴露水平；冶炼/精炼工人，高暴露水平）与糖尿病及糖尿病前期风险之间的关联。
糖尿病和糖尿病前期的总体患病率分别为7.5%和16.8%。与办公室工作人员相比，采矿/生产工人和冶炼/精炼工人患糖尿病的调整比值比分别为1.5（95%置信区间：1.3，1.7）和3.8（95%置信区间：3.4，4.3）。本研究中未观察到这些职业组与糖尿病前期之间存在关联。
在该队列中，与较高金属暴露水平相关的职业与糖尿病风险增加有关。需要更多研究来证实这一观察到的关联。
