Marques-Vidal P, Vollenweider P, Waeber G
Department of Internal Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Nutr Metab Cardiovasc Dis. 2015 Jan;25(1):75-84. doi: 10.1016/j.numecd.2014.08.010. Epub 2014 Sep 16.
Moderate alcohol consumption has been shown to decrease the risk of type 2 diabetes (T2DM), but whether this association is also valid for impaired fasting glucose (IFG) is less well known. We aimed at assessing the impact of alcohol consumption and of type of alcoholic beverage on the incidence of T2DM and T2DM + IFG.
As many as 4765 participants (2613 women, mean age 51.7 ± 10.5 years) without T2DM at baseline and followed for an average of 5.5 years. The association between alcohol consumption, type of alcoholic beverage and outcomes was assessed after adjustment for a validated T2DM risk score. During follow-up 284 participants developed T2DM and 643 developed IFG. On bivariate analysis, alcohol consumption was positively associated with the risk of developing T2DM or T2DM + IFG. Moderate (14-27 units/week) alcohol consumption tended to be associated with a lower risk of T2DM, but no protective effect was found for T2DM + IFG. Multivariable-adjusted odds ratio (OR) and (95% confidence interval) for T2DM: 0.89 (0.65-1.22), 0.66 (0.42-1.03) and 1.63 (0.93-2.84) for 1-13, 14-27 and 28 + units/week, respectively (p for quadratic trend < 0.005). For T2DM + IFG, the corresponding ORs were 1.09 (0.90-1.32), 1.33 (1.02-1.74) and 1.54 (0.99-2.39), respectively, p for trend = 0.03. No specific effect of alcoholic beverage (wine, beer or spirits) was found for T2DM or for T2DM + IFG.
Moderate alcohol consumption is associated with a reduced risk of developing T2DM, but not of developing T2DM + IFG. No specific effect of type of alcoholic beverage was found.
适度饮酒已被证明可降低2型糖尿病（T2DM）的风险，但这种关联对于空腹血糖受损（IFG）是否也成立尚鲜为人知。我们旨在评估饮酒量及酒精饮料类型对T2DM和T2DM + IFG发病率的影响。
共有4765名参与者（2613名女性，平均年龄51.7±10.5岁），基线时无T2DM，平均随访5.5年。在对经过验证的T2DM风险评分进行校正后，评估饮酒量、酒精饮料类型与结局之间的关联。随访期间，284名参与者患T2DM，643名参与者出现IFG。在双变量分析中，饮酒与患T2DM或T2DM + IFG的风险呈正相关。适度饮酒（每周14 - 27个单位）往往与较低的T2DM风险相关，但未发现对T2DM + IFG有保护作用。T2DM的多变量调整优势比（OR）及（95%置信区间）：每周1 - 13、14 - 27和28 +个单位分别为0.89（0.65 - 1.22）、0.66（0.42 - 1.03）和1.63（0.93 - 2.84）（二次趋势p < 0.005）。对于T2DM + IFG，相应的OR分别为1.09（0.90 - 1.32）、1.33（1.02 - 1.74）和1.54（0.99 - 2.39），趋势p = 0.03。未发现酒精饮料（葡萄酒、啤酒或烈酒）对T2DM或T2DM + IFG有特定影响。
适度饮酒与降低患T2DM的风险相关，但与降低T2DM + IFG的风险无关。未发现酒精饮料类型有特定影响。
