Mallah Manthar Ali, Liu Min, Liu Yu, Xu Hai-Feng, Wu Xiao-Jun, Chen Xiao-Tian, Wang Hui, Liu Chun-Lan, Tian Yuan-Rui, Li Meng-Xia, Li Qun, Fu Jun, Shen Chong
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Center for Disease Control and Prevention of Jurong City, Jurong, Jiangsu 212402, China.
Chronic Dis Transl Med. 2019 Jun 24;5(2):113-121. doi: 10.1016/j.cdtm.2019.05.004. eCollection 2019 Jun.
Handgrip strength (HGS) exercise has been reported to reduce blood pressure in both hypertensive and normotensive patients. In this study, we evaluated the association of HGS with hypertension in a Chinese Han Population.
A total of 11,151 subjects mainly consisting of a rural population were recruited with a multi-stage sampling method in Jurong city, Jiangsu Province, China. Besides hypertension and diabetes, major chronic diseases were excluded. HGS was categorized into tertiles by age and gender. Logistic regression was used to estimate the association of HGS and hypertension with the odds ratio () and 95% confidence interval ().
From low to high tertiles of HGS, diastolic blood pressure (DBP) was significantly increased (74.52 ± 7.39, 74.70 ± 7.03, and 75.54 ± 7.01 mmHg, respectively; = 0.001), as well as in females ( 0.003). The differences in DBP among the tertiles of HGS were still significant in females even after adjusting for covariates ( 0.048). No significant differences in systolic blood pressure (SBP) were observed among the tertiles of HGS (>0.05). Compared to low HGS, high HGS was significantly associated with hypertension after adjustment for age and gender (adjusted , 1.19; 95% , 1.06-1.34; =0.004). A stratified analysis showed that the significant association of high HGS and hypertension was also observed with the following factors even after adjusting for age and gender: female gender (adjusted , 1.25; 95% 1.08-1.46; =0.004), ages of 60-69 years (adjusted , 1.29; 95% 1.06-1.57; =0.011), and married (adjusted , 1.20; 95% 1.06-1.37; =0.005). However, no significant associations were found after adjusting for age, gender, smoking status, drinking status, body mass index, physical activity level, glucose, high- and low-density lipoprotein cholesterol, total cholesterol, and triglyceride (>0.05).
The findings of the current study suggest that HGS was positively correlated with DBP in a rural population, and high HGS was associated with hypertension in females; however, the association may be modified by smoking status, drinking status, body mass index, physical activity, cholesterol level, and glucose level. Further utilization of HGS exercises to intervene in the development and prognosis of hypertension should be verified in the future.
据报道，握力（HGS）锻炼可降低高血压患者和血压正常者的血压。在本研究中，我们评估了中国汉族人群中握力与高血压的关联。
在中国江苏省句容市采用多阶段抽样方法共招募了11151名主要由农村人口组成的受试者。除高血压和糖尿病外，排除了其他主要慢性病。根据年龄和性别将握力分为三个三分位数。采用逻辑回归分析来估计握力与高血压的关联，并计算比值比（OR）和95%置信区间（CI）。
从握力的低三分位数到高三分位数，舒张压（DBP）显著升高（分别为74.52±7.39、74.70±7.03和75.54±7.01 mmHg；P = 0.001），女性中也是如此（P = 0.003）。即使在调整协变量后，女性握力三分位数间的舒张压差异仍然显著（P = 0.048）。在握力的三分位数间未观察到收缩压（SBP）有显著差异（P>0.05）。与低握力相比，在调整年龄和性别后，高握力与高血压显著相关（调整后的OR，1.19；95%CI，1.06 - 1.34；P = 0.004）。分层分析表明，即使在调整年龄和性别后，在以下因素中也观察到高握力与高血压的显著关联：女性（调整后的OR，1.25；95%CI，1.08 - 1.46；P = 0.004）、60 - 69岁年龄组（调整后的OR，1.29；95%CI，1.06 - 1.57；P = 0.011）以及已婚者（调整后的OR，1.20；95%CI，1.06 - 1.37；P = 0.005）。然而，在调整年龄、性别、吸烟状况、饮酒状况、体重指数、身体活动水平、血糖、高密度和低密度脂蛋白胆固醇、总胆固醇以及甘油三酯后，未发现显著关联（P>0.05）。
本研究结果表明，在农村人群中握力与舒张压呈正相关，高握力与女性高血压相关；然而，这种关联可能会受到吸烟状况、饮酒状况、体重指数、身体活动、胆固醇水平和血糖水平的影响。未来应进一步验证利用握力锻炼干预高血压的发生发展和预后情况。
