Guangdong Engineering Research Center of Natural Products and New Drugs, Guangdong Provincial University Engineering Technology Research Center of Natural Products and Drugs, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Guangdong Metabolic Diseases Research Centre of Integrated Chinese and Western Medicine, Guangdong TCM Key Laboratory for Metabolic Diseases, Key Laboratory of Modulating Liver to Treat Hyperlipemia SATCM, Level 3 Laboratory of Lipid Metabolism SATCM, Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University, Guangzhou, 510006, China.
Eur J Clin Microbiol Infect Dis. 2019 Nov;38(11):1987-1998. doi: 10.1007/s10096-019-03623-x. Epub 2019 Jul 31.
The potential role of the gut microbiota in various human diseases has attracted considerable attention worldwide. Here, we discuss the vital role of the intestinal microbiota in the development of obesity. First, we describe how the gut microbiota promotes fat accumulation. Additionally, a high-fat diet leads to structural instability among in the gut microbiota, further leading to an increase in endotoxins, which aggravates obesity. We then discuss how gut microbiota metabolites, including short-chain fatty acids and lipopolysaccharides, affect the host. Finally, we review several strategies for regulating the intestinal flora.
肠道微生物群在各种人类疾病中的潜在作用引起了全世界的广泛关注。在这里，我们讨论肠道微生物群在肥胖发展中的重要作用。首先，我们描述了肠道微生物群如何促进脂肪积累。此外，高脂肪饮食会导致肠道微生物群的结构不稳定，进而导致内毒素增加，从而加剧肥胖。然后，我们讨论了肠道微生物群代谢物（包括短链脂肪酸和脂多糖）如何影响宿主。最后，我们综述了几种调节肠道菌群的策略。
