Veterinary Drug Residue Analysis Division, Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Bangladesh Atomic Energy Commission, Dhaka, Bangladesh.
School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, Woolloongabba, QLD, Australia.
J Food Biochem. 2019 Aug;43(8):e12958. doi: 10.1111/jfbc.12958. Epub 2019 Jun 17.
The study reports the phenolic composition of propolis from Bangladesh and its ameliorative effects against tetracycline-induced hepatonephrotoxicity in rats. Male Wistar Albino rats (n = 18) were randomly divided into three following groups: (1) normal control, (2) tetracycline-treatment (200 mg kg rat ), and (3) tetracycline (200 mg kg rat ) + propolis (100 mg kg rat ) treatments. The ethanolic extract of propolis contained major phenolic acids as well as a flavonoid, rutin. Oral exposure to tetracycline caused severe hepatic and renal damage as indicated by significant alterations in liver marker enzymes in rat serum: bilirubin and protein concentrations, lipid profile, and markers of kidney function when compared with controls. The observed biochemical perturbations were accompanied by histopathological changes. Co-administration with propolis extract, however, prevented the changes in biochemical parameters, as revealed by maintenance of cell membrane integrity and regulation of lipid profile and the conservation of the histoarchitecture. PRACTICAL APPLICATIONS: Propolis is a resinous honeybee product which is becoming increasingly popular due to its potential contributions to human health. The phenolic compounds identified in propolis from Bangladesh were effective against tetracycline-induced hepatic and renal toxicity. Propolis may be a promising natural product in reducing the effects of chronic liver and kidney damage.
本研究报告了来自孟加拉国的蜂胶的酚类成分及其对大鼠四环素诱导的肝肾病的改善作用。雄性 Wistar 白化大鼠（n=18）随机分为三组：（1）正常对照组，（2）四环素处理组（200mg/kg 大鼠），和（3）四环素（200mg/kg 大鼠）+蜂胶（100mg/kg 大鼠）处理组。蜂胶的乙醇提取物含有主要的酚酸和黄酮类化合物，芦丁。与对照组相比，口服暴露于四环素会导致大鼠血清中肝脏标志物酶的显著改变，表明肝脏和肾脏受到严重损害：胆红素和蛋白质浓度、脂质谱和肾功能标志物。观察到的生化扰动伴随着组织病理学变化。然而，与蜂胶提取物共同给药可防止生化参数的变化，这表现为细胞膜完整性的维持以及脂质谱的调节和组织形态的保存。
蜂胶是一种由蜜蜂分泌的树脂状产品，由于其对人类健康的潜在贡献，越来越受到欢迎。在来自孟加拉国的蜂胶中鉴定出的酚类化合物对四环素诱导的肝毒性和肾毒性有效。蜂胶可能是一种有前途的天然产物，可减少慢性肝和肾损伤的影响。
