Vo Nam Xuan, Xuan Doan Thy Bui, Kha Vo Di Ngoc, Tran Tu Kim, Vo Trung Quang
Graduate Program in Social, Economic and Administrative Pharmacy, Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.
J Pak Med Assoc. 2019 Jun;69(Suppl 2)(6):S137-S157.
One can hypothesize that Mycobacterium genus originated more than 150 million years ago and has evolved to become one of the leading lethal infectious diseases. Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) patients are directly affected by the disease and other subjective issues, such as related diseases, medical costs and social issues, which all have negative impacts on patient quality of life (QOL). Our purpose is to define the status of health-related QOL for international MDR-TB and XDR-TB patients.
Systematic review is a good method for searching and selecting related researches and articles. As such, we have searched for and cited related articles on reputable databases, such as PubMed, Cochrance, and Google Scholar. A data overview was performed to draw conclusions and results on the QOL of MDR-TB and XDR-TB patients.
A total of 18 articles were included, using instruments from the World Health Organization, Euroqol, Short Form, AQ and the Seattle Obstructive Lung Disease Questionnaire. The QOL of MDR-TB and XDR-TB patients was found to be compromised due to the strong resistance of Mycobacterium tuberculosis, economic pressure and community alienation.
A number of QOL and health-related QOL studies on MDR-TB and XDR-TB patients are limited, especially with XDR-TB patients. Significant numbers of MDR-TB and XDR-TB patients still have sequelae after completing treatment, reducing the health-related QOL among these patients.
可以推测分枝杆菌属起源于1.5亿多年前，并已演变成主要的致命传染病之一。耐多药结核病（MDR-TB）和广泛耐药结核病（XDR-TB）患者直接受到该疾病以及其他主观问题的影响，如相关疾病、医疗费用和社会问题，所有这些都对患者的生活质量（QOL）产生负面影响。我们的目的是确定国际MDR-TB和XDR-TB患者与健康相关的生活质量状况。
系统评价是搜索和选择相关研究及文章的好方法。因此，我们在知名数据库，如PubMed、Cochrance和谷歌学术上搜索并引用了相关文章。进行了数据概述，以得出关于MDR-TB和XDR-TB患者生活质量的结论和结果。
共纳入18篇文章，使用了世界卫生组织、欧洲五维度健康量表、简明健康调查问卷、AQ量表和西雅图阻塞性肺病问卷等工具。发现MDR-TB和XDR-TB患者的生活质量因结核分枝杆菌的强耐药性、经济压力和社区疏离感而受到损害。
关于MDR-TB和XDR-TB患者的生活质量及与健康相关的生活质量的研究数量有限，尤其是XDR-TB患者。大量MDR-TB和XDR-TB患者在完成治疗后仍有后遗症，降低了这些患者与健康相关的生活质量。
