• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

子宫内膜异位症加速早期胚胎细胞分裂的同步性，但不会改变子宫内膜异位症患者的形态动力学。

Endometriosis accelerates synchronization of early embryo cell divisions but does not change morphokinetic dynamics in endometriosis patients.

机构信息

Das Kinderwunsch Institut Schenk GmbH, Dobl, Austria.

Institute of Human Genetics, Medical University of Graz, Graz, Austria.

出版信息

PLoS One. 2019 Aug 1;14(8):e0220529. doi: 10.1371/journal.pone.0220529. eCollection 2019.

DOI:10.1371/journal.pone.0220529
PMID:31369616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6675061/
Abstract

OBJECTIVE

The pathology of endometriosis and its impact on embryo development is still a black box in reproductive medicine. In this time-lapse study we investigated the influence of endometriosis on morphokinetic parameters of embryo development, taking variables of dynamic monitoring into account. Furthermore we evaluated reproductive medicine treatment outcome such as fetal heartbeat and live birth rate.

METHODS

1148 embryos (control: n = 596, endometriosis: n = 552) were retrospectively analyzed. Patients were stimulated with GnRH antagonist protocol. After fertilization, embryos were incubated in a time-lapse system (EmbryoScope).

RESULTS

The mixed-model analysis revealed a significant main effect of time (p<0.001), with post-hoc tests showing that any time needed to reach a specific developmental stage was significantly different from all the others (all p<0.001). Embryos of endometriosis patients showed the same absolute morphokinetic time parameters as the control group, however, synchronization of early embryo cell divisions (s2) was faster in endometriosis patients compared to the control group.

CONCLUSION

In general, endometriosis does not induce changes in early embryo morphokinetics. However, observed acceleration in cell cycle synchronization of embryo cleavage patterns might be a missing explanation for contradicting results in literature regarding the impairments in reproductive medicine treatment outcome of endometriosis patients.

摘要

目的

子宫内膜异位症的病理学及其对胚胎发育的影响仍然是生殖医学中的一个“黑箱”。在这项时差培养研究中，我们调查了子宫内膜异位症对胚胎发育形态动力学参数的影响，同时考虑了动态监测的变量。此外，我们评估了生殖医学治疗结局，如胎儿心跳和活产率。

方法

回顾性分析了 1148 个胚胎（对照组：n=596，子宫内膜异位症组：n=552）。患者采用 GnRH 拮抗剂方案进行刺激。受精后，胚胎在时差培养系统（EmbryoScope）中进行培养。

结果

混合模型分析显示时间有显著的主效应（p<0.001），事后检验表明，达到特定发育阶段所需的任何时间都与其他时间显著不同（均 p<0.001）。子宫内膜异位症患者的胚胎与对照组具有相同的绝对形态动力学时间参数，但与对照组相比，子宫内膜异位症患者的早期胚胎细胞分裂（s2）同步更快。

结论

一般来说，子宫内膜异位症不会引起早期胚胎形态动力学的变化。然而，胚胎卵裂模式中细胞周期同步的观察到的加速可能是解释生殖医学治疗子宫内膜异位症患者结局受损的矛盾结果的一个缺失因素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7e/6675061/baf9fb40d389/pone.0220529.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7e/6675061/6e6a4fe7ca6b/pone.0220529.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7e/6675061/baf9fb40d389/pone.0220529.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7e/6675061/6e6a4fe7ca6b/pone.0220529.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7e/6675061/baf9fb40d389/pone.0220529.g002.jpg

相似文献

1
Endometriosis accelerates synchronization of early embryo cell divisions but does not change morphokinetic dynamics in endometriosis patients.子宫内膜异位症加速早期胚胎细胞分裂的同步性，但不会改变子宫内膜异位症患者的形态动力学。
PLoS One. 2019 Aug 1;14(8):e0220529. doi: 10.1371/journal.pone.0220529. eCollection 2019.
2
Timing of human preimplantation embryonic development is confounded by embryo origin.人类植入前胚胎发育的时间因胚胎来源而变得复杂。
Hum Reprod. 2016 Feb;31(2):324-31. doi: 10.1093/humrep/dev296. Epub 2015 Dec 4.
3
Early embryo morphokinetics is a better predictor of post-ICSI live birth than embryo morphology: speed is more important than beauty at the cleavage stage.早期胚胎形态动力学比胚胎形态学更能预测卵胞浆内单精子注射（ICSI）后的活产：在卵裂阶段，速度比外观更重要。
Zygote. 2021 Dec;29(6):495-502. doi: 10.1017/S0967199421000253. Epub 2021 Apr 29.
4
The impact of endometriosis on embryo morphokinetics: embryos from endometriosis patients exhibit delayed cell cycle milestones and decreased blastulation rates.子宫内膜异位症对胚胎形态动力学的影响：来自子宫内膜异位症患者的胚胎表现出细胞周期里程碑的延迟和囊胚形成率的降低。
J Assist Reprod Genet. 2022 Mar;39(3):619-628. doi: 10.1007/s10815-022-02406-2. Epub 2022 Jan 31.
5
Can novel early non-invasive biomarkers of embryo quality be identified with time-lapse imaging to predict live birth?能否通过延时成像技术识别胚胎质量的新型早期非侵入性生物标志物，从而预测活产？
Hum Reprod. 2019 Aug 1;34(8):1439-1449. doi: 10.1093/humrep/dez085.
6
Faster fertilization and cleavage kinetics reflect competence to achieve a live birth after intracytoplasmic sperm injection, but this association fades with maternal age.受精和卵裂速度更快反映了通过胞浆内单精子注射实现活产的能力，但这种关联会随着母亲年龄的增长而减弱。
Fertil Steril. 2021 Mar;115(3):665-672. doi: 10.1016/j.fertnstert.2020.06.023. Epub 2020 Sep 2.
7
Cumulative live birth rates after one ART cycle including all subsequent frozen-thaw cycles in 1050 women: secondary outcome of an RCT comparing GnRH-antagonist and GnRH-agonist protocols.1050名女性在一个辅助生殖技术周期（包括所有后续冻融周期）后的累积活产率：一项比较促性腺激素释放激素拮抗剂和促性腺激素释放激素激动剂方案的随机对照试验的次要结果。
Hum Reprod. 2017 Mar 1;32(3):556-567. doi: 10.1093/humrep/dew358.
8
Correlation between aneuploidy, standard morphology evaluation and morphokinetic development in 1730 biopsied blastocysts: a consecutive case series study.1730个活检囊胚的非整倍体、标准形态学评估与胚胎发育动力学之间的相关性：一项连续性病例系列研究
Hum Reprod. 2016 Oct;31(10):2245-54. doi: 10.1093/humrep/dew183. Epub 2016 Sep 2.
9
In vitro maturation is associated with increased early embryo arrest without impairing morphokinetic development of useable embryos progressing to blastocysts.体外成熟与早期胚胎阻滞增加有关，但不会损害可用胚胎的形态动力学发育，使其能够发育到囊胚阶段。
Hum Reprod. 2015 Aug;30(8):1842-9. doi: 10.1093/humrep/dev125. Epub 2015 Jun 3.
10
Time-lapse imaging derived morphokinetic variables reveal association with implantation and live birth following in vitro fertilization: A retrospective study using data from transferred human embryos.延时成像衍生的形态动力学变量与体外受精后种植和活产有关：一项使用移植人类胚胎数据的回顾性研究。
PLoS One. 2020 Nov 19;15(11):e0242377. doi: 10.1371/journal.pone.0242377. eCollection 2020.

引用本文的文献

1
Does endometriosis inflict harm on embryos? A systematic review of embryo morphokinetics analysed by time lapse monitoring in women with endometriosis.子宫内膜异位症是否会伤害胚胎？通过对子宫内膜异位症患者进行时间监测的胚胎形态动力学分析的系统综述。
Arch Gynecol Obstet. 2024 Apr;309(4):1191-1203. doi: 10.1007/s00404-023-07293-1. Epub 2023 Dec 8.
2
Knowledge-embedded spatio-temporal analysis for euploidy embryos identification in couples with chromosomal rearrangements.基于知识嵌入的时空分析在染色体结构重排夫妇中用于鉴定整倍体胚胎。
Chin Med J (Engl). 2024 Mar 20;137(6):694-703. doi: 10.1097/CM9.0000000000002803. Epub 2023 Aug 28.
3

本文引用的文献

1
The impact of endometriosis on early embryo morphokinetics: a case-control study.内异症对早期胚胎形态动力学的影响：病例对照研究。
Syst Biol Reprod Med. 2019 Jun;65(3):250-257. doi: 10.1080/19396368.2019.1573275. Epub 2019 Feb 11.
2
Methodological approaches to analyzing IVF data with multiple cycles.分析多个周期 IVF 数据的方法学方法。
Hum Reprod. 2019 Mar 1;34(3):549-557. doi: 10.1093/humrep/dey374.
3
Time-lapse systems for embryo incubation and assessment in assisted reproduction.辅助生殖中用于胚胎培养和评估的延时成像系统。
Morphokinetic analysis of early human embryonic development and its relationship to endometriosis resection: a retrospective time-lapse study using the KIDScore™ D3 and D5 implantation data algorithm.
早期人类胚胎发育的形态动力学分析及其与子宫内膜异位症切除的关系：使用 KIDScore™ D3 和 D5 植入数据算法的回顾性时差研究。
Arch Gynecol Obstet. 2023 Aug;308(2):587-597. doi: 10.1007/s00404-023-07008-6. Epub 2023 May 14.
4
Is Oocyte Quality Impaired in Cases With Ovarian Endometriosis? A Second Look Into the Clinical Setting.卵巢子宫内膜异位症患者的卵母细胞质量是否受损？对临床情况的再审视。
Front Endocrinol (Lausanne). 2022 Jun 30;13:921032. doi: 10.3389/fendo.2022.921032. eCollection 2022.
5
The impact of endometriosis on embryo morphokinetics: embryos from endometriosis patients exhibit delayed cell cycle milestones and decreased blastulation rates.子宫内膜异位症对胚胎形态动力学的影响：来自子宫内膜异位症患者的胚胎表现出细胞周期里程碑的延迟和囊胚形成率的降低。
J Assist Reprod Genet. 2022 Mar;39(3):619-628. doi: 10.1007/s10815-022-02406-2. Epub 2022 Jan 31.
6
Time-Lapse Embryo culture: A better understanding of embryo development and clinical application.延时胚胎培养：更好地理解胚胎发育和临床应用。
JBRA Assist Reprod. 2022 Aug 4;26(3):432-443. doi: 10.5935/1518-0557.20210107.
7
Pronounced Trace Element Variation in Follicular Fluids of Subfertile Women Undergoing Assisted Reproduction.滤泡液中痕量元素的变化与接受辅助生殖技术的不孕女性。
Nutrients. 2021 Nov 19;13(11):4134. doi: 10.3390/nu13114134.
8
Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality.子宫内膜异位症通过减少胚胎数量而非降低胚胎质量来降低体外受精（IVF）的累积活产率。
J Clin Med. 2020 Aug 1;9(8):2478. doi: 10.3390/jcm9082478.
9
Expression of nm23-H1, p53, and integrin β1 in endometriosis and their clinical significance.nm23-H1、p53及整合素β1在子宫内膜异位症中的表达及其临床意义。
Int J Clin Exp Pathol. 2020 May 1;13(5):1024-1029. eCollection 2020.
Cochrane Database Syst Rev. 2018 May 25;5(5):CD011320. doi: 10.1002/14651858.CD011320.pub3.
4
Relative Morphokinetics Assessed by Time-Lapse Imaging Are Altered in Embryos From Patients With Endometriosis.通过延时成像评估的相对形态动力学在子宫内膜异位症患者的胚胎中发生改变。
Reprod Sci. 2018 Aug;25(8):1279-1285. doi: 10.1177/1933719117741373. Epub 2017 Nov 15.
5
Is the oocyte quality affected by endometriosis? A review of the literature.子宫内膜异位症会影响卵母细胞质量吗？文献综述。
J Ovarian Res. 2017 Jul 12;10(1):43. doi: 10.1186/s13048-017-0341-4.
6
Anti-Mullerian hormone concentrations in individual follicular fluids within one stimulated IVF cycle resemble blood serum values.在单个刺激 IVF 周期内，单个卵泡液中的抗苗勒氏管激素浓度类似于血清值。
J Assist Reprod Genet. 2017 Sep;34(9):1115-1120. doi: 10.1007/s10815-017-0908-4. Epub 2017 Mar 21.
7
World Endometriosis Society consensus on the classification of endometriosis.世界子宫内膜异位症协会关于子宫内膜异位症分类的共识
Hum Reprod. 2017 Feb;32(2):315-324. doi: 10.1093/humrep/dew293. Epub 2016 Dec 5.
8
Biobanking of different body fluids within the frame of IVF-a standard operating procedure to improve reproductive biology research.体外受精框架内不同体液的生物样本库——改善生殖生物学研究的标准操作程序
J Assist Reprod Genet. 2017 Feb;34(2):283-290. doi: 10.1007/s10815-016-0847-5. Epub 2016 Nov 26.
9
Blastocyst vs cleavage-stage embryo transfer: systematic review and meta-analysis of reproductive outcomes.囊胚移植与卵裂期胚胎移植：生殖结局的系统评价和荟萃分析
Ultrasound Obstet Gynecol. 2017 May;49(5):583-591. doi: 10.1002/uog.17327. Epub 2017 Apr 10.
10
Blood biomarkers for the non-invasive diagnosis of endometriosis.用于子宫内膜异位症无创诊断的血液生物标志物。
Cochrane Database Syst Rev. 2016 May 1;2016(5):CD012179. doi: 10.1002/14651858.CD012179.