鉴定桑叶中的桑辛素 N 并评价其抗氧化活性。
Identification of moracin N in mulberry leaf and evaluation of antioxidant activity.
机构信息
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, 510650, China.
出版信息
Food Chem Toxicol. 2019 Oct;132:110730. doi: 10.1016/j.fct.2019.110730. Epub 2019 Jul 29.
Mulberry leaf is a newly accepted vegetable for daily diet. It tastes good and has multiple health benefits, including antioxidant and anti-inflammatory activities. However, the chemicals responsible for these health benefits remain unveiled. Prenylated phenolics are characteristic bioactive compounds in mulberry leaf, which are recognized as good antioxidants. In this work, moracin N was purified from mulberry leaf. It showed better antioxidant activities than resveratrol. The EC value of cellular antioxidant activity was 24.92 μM, and the IC value against DPPH radical was 40.00 μM. The prenyl group rendered the molecule more membrane affinity which improved the bioavailability. The furan ring was critical for the antioxidant behaviour. The cell viability test revealed that moracin N had a good safety. These results pointed out that moracin N contributed to the antioxidant activity of mulberry leaf.
桑叶是一种新被接受的日常饮食蔬菜。它味道鲜美，具有多种健康益处，包括抗氧化和抗炎活性。然而，负责这些健康益处的化学物质仍未被揭示。苯丙素酚类化合物是桑叶中的特征生物活性化合物，被认为是良好的抗氧化剂。在这项工作中，桑辛 N 从桑叶中被分离出来。它表现出比白藜芦醇更好的抗氧化活性。细胞抗氧化活性的 EC 值为 24.92 μM，对 DPPH 自由基的 IC 值为 40.00 μM。 该取代基使分子具有更好的膜亲和力，从而提高了生物利用度。呋喃环对于抗氧化行为至关重要。细胞活力测试表明，桑辛 N 具有良好的安全性。这些结果表明，桑辛 N 对桑叶的抗氧化活性有贡献。
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