Meldrum D R, Wisot A, Hamilton F, Gutlay A L, Huynh D, Kempton W
AMI-South Bay Hospital In Vitro Fertilization Center, Redondo Beach, California 90277.
Fertil Steril. 1988 Sep;50(3):400-2. doi: 10.1016/s0015-0282(16)60121-8.
The time course of suppression of ovarian estrogen production and follicular development with leuprolide was examined in 40 normal women before ovarian stimulation for in vitro fertilization (IVF). Initiation of leuprolide during the midluteal phase caused a significantly more prompt suppression than when treatment was started during the early follicular phase (day 1). Injection of the same total amount of leuprolide in two divided doses also caused a significantly more prompt suppression. These two methods were consistent enough to make routine use of leuprolide practical before ovarian stimulation for IVF.
在40名准备接受体外受精（IVF）卵巢刺激的正常女性中，研究了用亮丙瑞林抑制卵巢雌激素生成和卵泡发育的时间进程。在黄体中期开始使用亮丙瑞林，其抑制作用比在卵泡早期（第1天）开始治疗时明显更迅速。将相同总量的亮丙瑞林分两次注射也能产生明显更迅速的抑制作用。这两种方法的一致性足以使亮丙瑞林在IVF卵巢刺激前的常规使用变得切实可行。
