Department of Medical Ultrasound, Shanghai Tenth People's Hospital, Ultrasound Research and Education Institute, Tongji University School of Medicine, Shanghai, China; Thyroid Institute, Tongji University School of Medicine, Shanghai, China.
Department of Pathology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Ultrasound Med Biol. 2019 Oct;45(10):2612-2622. doi: 10.1016/j.ultrasmedbio.2019.06.421. Epub 2019 Jul 29.
Our study aimed to investigate the correlation of the imaging features obtained using conventional ultrasound (US) and elastography (conventional strain elastography of elasticity imaging [EI], virtual touch tissue imaging [VTI] and 2-D shear wave elastography [2-D-SWE] of virtual touch tissue imaging quantification [VTIQ]) with the clinicopathologic features and immunohistochemical (IHC) subtypes of breast cancer. The sample consisted of images from 202 patients with 206 breast lesions that were confirmed as breast cancers. Lesions with HER2 overexpression (luminal B HER2+ or HER2+) had higher mean shear wave velocity (SWV) values than the others. Older patients, lower histologic grade, no lymphovascular invasion and no lymph node metastasis were associated with luminal A (p < 0.001). There were significant differences in SWV values, histologic grade and lymph node status among the different pathologic types. This association may allow the use of 2-D-SWE in the pre-operative prediction of tumor characteristics and biologic activity, which may determine the prognosis in a non-invasive manner.
我们的研究旨在探讨常规超声（US）和弹性成像（弹性成像的常规应变弹性成像[EI]、虚拟触诊组织成像[VTI]和虚拟触诊组织成像定量[VTIQ]的 2-D 剪切波弹性成像[2-D-SWE]）的影像学特征与乳腺癌的临床病理特征和免疫组织化学（IHC）亚型之间的相关性。该样本由 202 名患者的 206 个乳腺病变图像组成，这些病变均被证实为乳腺癌。HER2 过表达（管腔 B HER2+或 HER2+）的病变具有更高的平均剪切波速度（SWV）值。较年长的患者、较低的组织学分级、无淋巴血管侵犯和无淋巴结转移与管腔 A 相关（p<0.001）。不同病理类型之间的 SWV 值、组织学分级和淋巴结状态存在显著差异。这种相关性可能允许在术前使用 2-D-SWE 预测肿瘤特征和生物学活性，从而以非侵入性的方式确定预后。
