van Klingeren B, Ansink-Schipper M C, Doornbos L, Lampe A S, Wagenvoort J H, Dessens-Kroon M, Verheuvel M
National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
J Antimicrob Chemother. 1988 Jun;21(6):737-44. doi: 10.1093/jac/21.6.737.
From 1983 to 1986 more than 2000 non-penicillinase producing Neisseria gonorrhoeae from Amsterdam, The Hague and Rotterdam were auxotyped and screened for susceptibility to 10 antibiotics by MIC determination. By far the commonest auxotypes were N.R. (non-requiring; 40%) and Pro- (proline requiring; 30%). During that period there was a substantial shift in the ratio of both auxotypes-roughly from 1:2 to 2:1-in The Hague. Pro- isolates were generally less susceptible than N.R. isolates, and there was a strong positive correlation between the MICs of the different drugs. The prevalence of isolates with a penicillin MIC equal to or above 0.5 IU/ml amounted to 14%, while in only 1% was the MIC above 1 IU/ml. Comparing our results with an earlier study by Stolz, Zwarte & Michel (1975, British Journal of Venereal Diseases 51, 257-64), the level of resistance to penicillin among non-PPNG has not significantly increased in The Netherlands since 1972. The prevalence of isolates showing relative resistance towards tetracycline and thiamphenicol (MIC 2-4 mg/l) decreased from approximately 20% in 1983/84 to approximately 10% in 1985/86, coinciding with a drop in the prevalence of Pro- isolates. All strains were susceptible to cefuroxime and spectinomycin and highly susceptible to cefotaxime and ciprofloxacin.
