Liu Hongxia, Yang Linqing
Jining Medical University, ShanDong Province.
Department of Gynecology, Affiliated Hospital of Jining Medical University, ShanDong Province, China.
Medicine (Baltimore). 2019 Aug;98(31):e16620. doi: 10.1097/MD.0000000000016620.
Psychological state of patients with ovarian cancer is worthy of attention. We aimed to investigate the levels of anxiety and depression in patients with ovarian cancer. We also investigated the dynamic changes in anxiety and depression levels after chemotherapy.A total of 228 females were included in this study. Among them, a total of 111 participants had ovarian cancer and 117 females who underwent a physical examination were selected as healthy controls. All patients enrolled were asked to fill in the Self-rating Depression Scale and the Self-rating Anxiety Scale. For patients with ovarian cancer, repeat questionnaires were measured after cycle 1 chemotherapy.The depression score of patients with ovarian cancer was 45.90 ± 10.19, significantly higher than in controls (36.08 ± 9.06, P < .001). Similar results were observed in respect of anxiety score. The score of ovarian cancer patients was 39.53 ± 12.92, significantly higher than of controls (32.15 ± 7.44, P < .001). Multivariate analyses were conducted, and the results showed that young age was the independent risk factor associated with depression among patients with ovarian cancer, while young age and singleness were the independent risk factors associated with anxiety. Repeat questionnaires were measured after chemotherapy. Interestingly, we found depression scores decreased from 45.90 ± 10.19 to 36.29 ± 8.98 after chemotherapy (P < .001), while anxiety score increased from 39.53 ± 12.92 to 42.75 ± 9.96 after chemotherapy (P = .009). Multivariate analysis suggested that only higher income and higher baseline depression score were the independent and most relevant risk factors associated with depression remission after chemotherapy. For patients with anxiety remission, only higher baseline anxiety score was the independent risk factor associated with anxiety remission.This study suggests that for patients with ovarian cancer, timely monitoring of the patient's psychological state, especially before and after chemotherapy treatment, is very important. Assessing the changes in the patient's psychological state, screening the population with risk factors, and prompt intervention by mobilizing social support may be effective in preventing depression and anxiety in such population.
卵巢癌患者的心理状态值得关注。我们旨在调查卵巢癌患者的焦虑和抑郁水平。我们还研究了化疗后焦虑和抑郁水平的动态变化。
本研究共纳入228名女性。其中，共有111名参与者患有卵巢癌，117名接受体检的女性被选为健康对照。所有入选患者均被要求填写自评抑郁量表和自评焦虑量表。对于卵巢癌患者，在第1周期化疗后重复测量问卷。
卵巢癌患者的抑郁评分为45.90±10.19，显著高于对照组（36.08±9.06，P<.001）。焦虑评分方面也观察到类似结果。卵巢癌患者的评分为39.53±12.92，显著高于对照组（32.15±7.44，P<.001）。进行多因素分析，结果显示年龄较小是卵巢癌患者抑郁的独立危险因素，而年龄较小和单身是焦虑的独立危险因素。化疗后重复测量问卷。有趣的是，我们发现化疗后抑郁评分从45.90±10.19降至36.29±8.98（P<.001），而焦虑评分从39.53±12.92升至42.75±9.96（P=.009）。多因素分析表明，只有较高收入和较高的基线抑郁评分是化疗后抑郁缓解的独立且最相关危险因素。对于焦虑缓解的患者，只有较高的基线焦虑评分是焦虑缓解的独立危险因素。
本研究表明，对于卵巢癌患者，及时监测患者的心理状态，尤其是化疗治疗前后，非常重要。评估患者心理状态的变化，筛查有危险因素的人群，并通过动员社会支持进行及时干预，可能有效预防此类人群的抑郁和焦虑。
