Morais Débora Moreira, Trombim Isadora Cordeiro, de Góes Cassiana Regina, Vogt Barbara Perez
Faculty of Medicine, Federal University of Uberlandia (UFU), Uberlandia, Brazil.
Institute of Biological and Health Sciences, Federal University of Viçosa, Campus Rio Paranaíba, Rio Paranaíba, Brazil.
Front Nutr. 2025 Jan 22;11:1502309. doi: 10.3389/fnut.2024.1502309. eCollection 2024.
The adductor pollicis muscle thickness (APMT) may be associated with the muscle strength in patients on hemodialysis. However, the association of APMT with other physical function assessment tests has not yet been tested. Moreover, because it is considered a good nutritional indicator and not influenced by fluid overload, the APMT may be associated with the muscle mass and nutritional status of these patients. Therefore, the objective was to assess the association of APMT with physical function, muscle mass and nutritional status in patients on hemodialysis.
The APMT was measured using a skinfold caliper between pollicis finger and index finger. Physical function was evaluated by handgrip strength (HGS), Short Physical Performance Battery (SPPB), the sit-to-stand test, gait speed test, and timed up and go (TUG). Appendicular muscle mass index (AMMI) was estimated using bioelectrical impedance. The nutritional status was evaluated by the Malnutrition Inflammation Score (MIS).
Fifty-one patients were included, 60.8% men, mean age 58.4 ± 12.6 years. There were no significant correlations of APMT with physical function, muscle mass and nutritional status. Values of APMT were not different between the groups according to adequate physical function or muscle mass. In the multiple linear regression analysis adjusted for sex, age and diabetes, APMT was not significantly associated with physical function tests, as HGS ( = 0.101; = 0.778), gait speed ( = -0.014; = 0.180), SPPB ( = -0.054; = 0.590), TUG ( = 0.202; = 0.109), lean mass AMMI ( = 0.058; = 0.147).
There were no associations of APMT with physical function, muscle mass and nutritional status in patients on hemodialysis. We suggest APMT should not be used in physical function and nutritional assessments of these patients.
拇收肌厚度（APMT）可能与血液透析患者的肌肉力量有关。然而，APMT与其他身体功能评估测试之间的关联尚未得到验证。此外，由于APMT被认为是一个良好的营养指标且不受液体超负荷的影响，它可能与这些患者的肌肉质量和营养状况有关。因此，本研究旨在评估血液透析患者中APMT与身体功能、肌肉质量和营养状况之间的关联。
使用皮褶卡尺测量拇指和食指之间的APMT。通过握力（HGS）、简短身体功能测试电池（SPPB）、坐立试验、步速测试和计时起立行走测试（TUG）评估身体功能。使用生物电阻抗法估算四肢肌肉质量指数（AMMI）。通过营养不良炎症评分（MIS）评估营养状况。
纳入51例患者，其中男性占60.8%，平均年龄58.4±12.6岁。APMT与身体功能、肌肉质量和营养状况之间无显著相关性。根据身体功能或肌肉质量是否正常，各亚组之间的APMT值无差异。在对性别、年龄和糖尿病进行校正的多元线性回归分析中，APMT与身体功能测试无显著关联，如握力（β = 0.101；P = 0.778）、步速（β = -0.014；P = 0.180）、SPPB（β = -0.054；P = 0.590）、TUG（β = 0.202；P = 0.109）、瘦体重AMMI（β = 0.058；P = 0.147）。
血液透析患者中APMT与身体功能、肌肉质量和营养状况之间无关联。我们建议，在对这些患者进行身体功能和营养评估时，不应使用APMT。
