Wilcockson Thomas D W, Mardanbegi Diako, Xia Baiqiang, Taylor Simon, Sawyer Pete, Gellersen Hans W, Leroi Ira, Killick Rebecca, Crawford Trevor J
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
Psychology Department, Lancaster University, Lancaster, UK.
Aging (Albany NY). 2019 Aug 2;11(15):5389-5398. doi: 10.18632/aging.102118.
Background There is increasing evidence that people in the early stages of Alzheimer's disease (AD) have subtle impairments in cognitive inhibition that can be detected by using relatively simple eye-tracking paradigms, but these subtle impairments are often missed by traditional cognitive assessments. People with mild cognitive impairment (MCI) are at an increased likelihood of dementia due to AD. No study has yet investigated and contrasted the MCI subtypes in relation to eye movement performance. Methods In this work we explore whether eye-tracking impairments can distinguish between patients with the amnesic and the non-amnesic variants of MCI. Participants were 68 people with dementia due to AD, 42 had a diagnosis of aMCI, and 47 had a diagnosis of naMCI, and 92 age-matched cognitively healthy controls. Results: The findings revealed that eye-tracking can distinguish between the two forms of MCI. Conclusions The work provides further support for eye-tracking as a useful diagnostic biomarker in the assessment of dementia.
越来越多的证据表明，阿尔茨海默病（AD）早期患者存在认知抑制方面的细微损伤，可通过相对简单的眼动追踪范式检测到，但这些细微损伤往往会被传统认知评估所遗漏。轻度认知障碍（MCI）患者因AD患痴呆症的可能性增加。尚无研究调查并对比MCI亚型与眼动表现的关系。方法：在本研究中，我们探究眼动追踪损伤是否能区分遗忘型和非遗忘型MCI患者。参与者包括68名因AD导致痴呆的患者、42名被诊断为aMCI的患者、47名被诊断为naMCI的患者以及92名年龄匹配的认知健康对照者。结果：研究结果表明，眼动追踪能够区分这两种形式的MCI。结论：该研究进一步支持了眼动追踪作为痴呆评估中一种有用的诊断生物标志物的观点。
