视神经脊髓炎谱系疾病（NMOSD）女性的血压和体脂百分比。
Blood pressure and body fat percent in women with NMOSD.
机构信息
Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, Guangdong, China.
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.
出版信息
Brain Behav. 2019 Sep;9(9):e01350. doi: 10.1002/brb3.1350. Epub 2019 Aug 3.
BACKGROUND
Hypertension is a prevalent and impactful comorbid condition among patients with multiple sclerosis (MS). High level of body mass index (BMI) is associated with the risk and poor outcomes of neuromyelitis optica spectrum disorder (NMOSD) in women. However, the clinical implication of blood pressure (BP) and body fat percent (BF%) based on the Clínica Universidad de Navarra-Body Adiposity Estimator (CUN-BAE) in NMOSD has not been investigated thus far.
METHODS
Case data were collected from 47 NMOSD and 28 MS patients at acute phase, 21 NMOSD and 25 MS patients at stable phase, and 68 age- and sex-matched HCs. Four BP measures including systolic BP (SBP), diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP); BMI; and BF% between NMOSD, MS, and healthy controls were determined.
RESULTS
Comparing NMOSD patients with MS patients, the former have significantly higher SBP (p < 0.001), DBP (p < 0.001), PP (p < 0.001), MAP (p < 0.001), BF% (p = 0.001), and BMI (p < 0.001) levels at acute phase after adjusting for age. Acute myelitis (OR 3.719, 95% CI 1.110-12.453) is more likely to occur in NMOSD patients with high BF% (≥30%) at acute phase. BF% was negatively correlated with 1/AQP4 titer in NMOSD at acute phase (r = -0.522, p = 0.004).
CONCLUSIONS
Women with NMOSD are probably more prone to have an increased BP and fat mass compared to MS.
背景
高血压是多发性硬化症（MS）患者中一种普遍且影响较大的合并症。高体重指数（BMI）与女性视神经脊髓炎谱系疾病（NMOSD）的风险和不良预后相关。然而，基于 Clínica Universidad de Navarra-Body Adiposity Estimator（CUN-BAE）的血压（BP）和体脂肪百分比（BF%）在 NMOSD 中的临床意义尚未得到研究。
方法
从急性期的 47 名 NMOSD 和 28 名 MS 患者、稳定期的 21 名 NMOSD 和 25 名 MS 患者以及 68 名年龄和性别匹配的健康对照者中收集病例数据。测定了包括收缩压（SBP）、舒张压（DBP）、脉压（PP）和平均动脉压（MAP）在内的 4 项 BP 指标；BMI；以及 NMOSD、MS 和健康对照组之间的 BF%。
结果
与 MS 患者相比，NMOSD 患者在急性发作时的 SBP（p<0.001）、DBP（p<0.001）、PP（p<0.001）、MAP（p<0.001）、BF%（p=0.001）和 BMI（p<0.001）水平明显更高，且在调整年龄后仍具有统计学意义。在急性发作时，BF%≥30%的 NMOSD 患者更容易发生急性脊髓炎（OR 3.719，95%CI 1.110-12.453）。在急性发作时，NMOSD 患者的 BF%与 1/AQP4 滴度呈负相关（r=-0.522，p=0.004）。
结论
与 MS 相比，NMOSD 女性可能更容易出现血压和脂肪量升高。
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