2019 年回顾：系统性红斑狼疮。

One year in review 2019: systemic lupus erythematosus.

机构信息

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, and Department of Medical Biotechnologies, University of Siena, Italy.

出版信息

Clin Exp Rheumatol. 2019 Sep-Oct;37(5):715-722. Epub 2019 Jul 19.

PMID:31376267

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune connective-tissue disorder with a wide range of clinical manifestations that predominantly affect women. Many aspects of its pathogenesis are still unclear, and new therapeutic strategies are progressively emerging. Thus, in this review we aim to summarise the most relevant data on SLE that emerged during 2018, following the previous annual review of this series. In particular, the review will focus on new insights in SLE regarding new pathogenetic pathways, new biomarkers, new data on clinical manifestations, clinical outcomes and comorbidities and what has emerged on new drugs and new therapeutic strategies.

摘要

系统性红斑狼疮（SLE）是一种自身免疫性结缔组织疾病，临床表现广泛，主要影响女性。其发病机制的许多方面仍不清楚，新的治疗策略也在不断涌现。因此，在本综述中，我们旨在总结 2018 年出现的与 SLE 相关的最相关数据，该综述是该系列年度综述的延续。具体而言，该综述将重点介绍 SLE 在新发病机制途径、新生物标志物、临床表现、临床结局和合并症方面的新数据，以及新药物和新治疗策略方面的新进展。