Kitagawa Hiroki, Ohge Hiroki, Hisatsune Junzo, Masuda Kanako, Aziz Fatkhanuddin, Hara Toshinori, Kuroo Yuta, Sugai Motoyuki
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima 734-8551, Japan; Department of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima 734-8551, Japan; Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima 734-8551, Japan.
J Infect Chemother. 2020 Jan;26(1):140-143. doi: 10.1016/j.jiac.2019.07.011. Epub 2019 Jul 31.
Staphylococcus argenteus is a globally distributed cause of human infection; however, it has been misidentified as Staphylococcus aureus in diagnostic laboratories. Invasive infection caused by S. argenteus has been increasingly reported worldwide. However, there have been no reports on S. argenteus bacteremia in Japan. Therefore, we conducted a retrospective study to investigate the incidence of S. argenteus bacteremia at Hiroshima University Hospital between 2013 and 2017. S. argenteus was identified based on the absence of the crtM gene and multi-locus sequence typing. S. argenteus was identified in 2 of the 201 S. aureus blood culture isolates (1.0%). Both S. argenteus isolates belonged to sequence type 2250 harboring the staphylococcal enterotoxin Y gene (sey) and were susceptible to methicillin. One of them was penicillin-resistant, harboring a blaZ gene. The primary sites of infection were lower leg cellulitis and catheter-related blood stream infection. No patients died during hospitalization. This study suggested a low incidence of S. argenteus bacteremia in Japan when compared with reports from other countries. Further studies are necessary to investigate the prevalence of S. argenteus infection in Japan and the clinical impact of S. argenteus compared to S. aureus.
银色葡萄球菌是一种在全球范围内引发人类感染的病原体；然而，在诊断实验室中它一直被误鉴定为金黄色葡萄球菌。由银色葡萄球菌引起的侵袭性感染在全球范围内的报道日益增多。然而，日本尚无关于银色葡萄球菌菌血症的报告。因此，我们进行了一项回顾性研究，以调查2013年至2017年间广岛大学医院银色葡萄球菌菌血症的发病率。银色葡萄球菌是根据缺乏crtM基因和多位点序列分型来鉴定的。在201株金黄色葡萄球菌血培养分离株中有2株鉴定为银色葡萄球菌（1.0%）。这两株银色葡萄球菌分离株均属于序列型2250，携带葡萄球菌肠毒素Y基因（sey），且对甲氧西林敏感。其中一株对青霉素耐药，携带blaZ基因。感染的主要部位是小腿蜂窝织炎和导管相关血流感染。住院期间无患者死亡。这项研究表明，与其他国家的报告相比，日本银色葡萄球菌菌血症的发病率较低。有必要进一步研究以调查日本银色葡萄球菌感染的流行情况以及与金黄色葡萄球菌相比银色葡萄球菌的临床影响。
