Okumura Nobumasa, Kutsuna Satoshi, Tsukada Akinari, Mezaki Kazuhisa, Nagashima Maki, Ohmagari Norio
Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan.
Department of Infectious Diseases, Nagoya City University East Medical Center, Aichi, Japan.
IJID Reg. 2024 Sep 5;13:100443. doi: 10.1016/j.ijregi.2024.100443. eCollection 2024 Dec.
There is a paucity of data on the clinical course and treatment of . Herein, we describe a successfully treated case of bacteremia. A 76-year-old man with lung adenocarcinoma developed bacteremia caused by penicillin-resistant, oxacillin-susceptible , which was identified through mass spectrometry and gene sequencing. He was diagnosed with a peripheral line-associated bloodstream infection and successfully treated with a 2-week course of cefepime, followed by cefazolin, concurrent with intravenous catheter removal. The isolate was positive for and negative for . It was assigned to sequence type 2198 using multilocus sequence typing. Formerly classified as clonal complex 75, became a distinct species in 2015. Its identification has increased owing to widespread mass spectrometer use. Most East and Southeast Asian isolates reported to date are methicillin-susceptible, consistent with the susceptibility pattern of the isolate in our study. Given the potential equivalence in virulence between and , we recommend treating with the same rigor as until further clinical data becomes available.
关于……的临床病程和治疗的数据匮乏。在此，我们描述一例成功治疗的……菌血症病例。一名76岁的肺腺癌男性发生了由对青霉素耐药、对苯唑西林敏感的……引起的菌血症，该菌通过质谱分析和……基因测序得以鉴定。他被诊断为外周静脉导管相关血流感染，并成功接受了为期2周的头孢吡肟治疗，随后使用头孢唑林，同时拔除静脉导管。分离株……呈阳性，……呈阴性。使用多位点序列分型将其归为序列型2198。……以前被归类为……克隆复合体75，在2015年成为一个独特的物种。由于质谱仪的广泛使用，其鉴定率有所提高。迄今为止报道的大多数东亚和东南亚……分离株对甲氧西林敏感，与我们研究中分离株的药敏模式一致。鉴于……和……在毒力上可能相当，我们建议在获得更多临床数据之前，以与……相同的严格程度治疗……。
