ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
ENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, 200031, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China.
Neurosci Lett. 2019 Oct 15;711:134406. doi: 10.1016/j.neulet.2019.134406. Epub 2019 Aug 1.
The cochlea is the essential organ for hearing and includes both auditory sensory hair cells and spiral ganglion neurons. The discovery of inner ear stem cell brings hope to the regeneration of hair cell and spiral ganglion neuron as well as the followed hearing re-establishment. Thus the investigation on characteristics of inner ear stem/progenitor cells and related regulating clue is important to make such regeneration a reality. In addition, attempts have also been made to transplant exogenous stem cells into the inner ear to restore hearing function. In this review, we describe recent advances in the characterization of mammalian inner ear progenitor/stem cells and the mechanisms of regulating their proliferation and differentiation, and summarize studies that have used exogenous stem cells to repair damaged hair cells and neurons in the inner ear.
耳蜗是听觉的重要器官，包含听觉感觉毛细胞和螺旋神经节神经元。内耳干细胞的发现为毛细胞和螺旋神经节神经元的再生以及随后的听力重建带来了希望。因此，对内耳干细胞/祖细胞的特性及相关调节线索的研究对于实现这种再生具有重要意义。此外，人们还尝试将外源性干细胞移植到内耳中以恢复听力功能。在这篇综述中，我们描述了哺乳动物内耳祖细胞/干细胞的特征及其增殖和分化调节机制的最新进展，并总结了利用外源性干细胞修复内耳损伤的毛细胞和神经元的研究。
