[慢性尿毒症患者催乳素和生长激素的基础分泌及刺激后分泌]
[Basal and stimulated secretion of prolactin and growth hormone in patients with chronic uremia].
作者信息
Rudolf K, Kunkel S, Rudolf H, Falkenhagen D, Rüting M
机构信息
Klinik für Gynäkologie und Geburtshilfe, Bereichs Medizin, Wilhelm-Pieck-Universität Rostock.
出版信息
Zentralbl Gynakol. 1988;110(11):693-7.
In 11 patients with chronic uremia both the basal and the stimulated levels of PRL and HGH were determined by RIA. The investigations were repeated in 2 patients after renal transplantation. The basal PRL levels were as well hyper- and normoprolactinemic as hypoprolactinemic. Also the PRL response did not show any uniform tendency to the TRH stimulation. After renal transplantation in 1 patient there was a decrease of the hyperprolactinemic serum levels into the normoprolactinemic range whereas the response was not influenced to TRH. Both the basal and the stimulated levels of HGH were in the physiological range. The response of HGH to the stimulation is explained as the so-called paradox TRH effect underlined by missing of the stimulation after renal transplantation.
对11例慢性尿毒症患者采用放射免疫分析法测定了基础及刺激状态下的催乳素（PRL）和生长激素（HGH）水平。2例患者肾移植后重复进行了检测。基础PRL水平既有高催乳素血症、正常催乳素血症，也有低催乳素血症。PRL对促甲状腺激素释放激素（TRH）刺激的反应也未表现出任何一致的倾向。1例患者肾移植后，高催乳素血症的血清水平降至正常催乳素血症范围，而其对TRH的反应未受影响。基础及刺激状态下的HGH水平均在生理范围内。HGH对刺激的反应被解释为所谓的矛盾TRH效应，肾移植后刺激缺失突出了这一点。
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