[Basal and stimulated secretion of prolactin and growth hormone in patients with chronic uremia].

In 11 patients with chronic uremia both the basal and the stimulated levels of PRL and HGH were determined by RIA. The investigations were repeated in 2 patients after renal transplantation. The basal PRL levels were as well hyper- and normoprolactinemic as hypoprolactinemic. Also the PRL response did not show any uniform tendency to the TRH stimulation. After renal transplantation in 1 patient there was a decrease of the hyperprolactinemic serum levels into the normoprolactinemic range whereas the response was not influenced to TRH. Both the basal and the stimulated levels of HGH were in the physiological range. The response of HGH to the stimulation is explained as the so-called paradox TRH effect underlined by missing of the stimulation after renal transplantation.