Karaca Aysegul, Yilmaz Seval, Kaya Emre, Altun Serdar
Faculty of Pharmacy, Department of Biochemistry, Inonu University, Malatya, Turkey.
Faculty of Veterinary Medicine, Department of Biochemistry, Firat University, Elazig, Turkey.
Arch Physiol Biochem. 2021 Oct;127(5):429-436. doi: 10.1080/13813455.2019.1648516. Epub 2019 Aug 5.
Oxidative damage caused by aflatoxin (AF) in rat liver tissue and the inhibition effect of lycopene against this injury was investigated. Groups were formed as; control group (not treated), lycopene group (5 mg/kg/day, gavage for 15 days), AFB1 group (0.5 mg/kg/day, gavage for 7 days) and AFB1 + lycopene group. Lycopene administered simultaneously with AFB1. It was observed significant increase in malondialdehyde level, decrease in glutathione level, antioxidant enzyme activities in liver tissue of AFB1 group when compared with control group. It was determined to significantly increase in plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase activities in AFB1 group when compared with control group. It was determined significant decrease in malondialdehyde level, plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase activities and increase in glutathione level, antioxidant enzyme activities in AFB1 + lycopene group when compared with AFB1 group. This study suggests that lycopene which has antioxidant properties can be prevented from AFB1 induced hepatotoxicity.
研究了黄曲霉毒素（AF）对大鼠肝脏组织造成的氧化损伤以及番茄红素对该损伤的抑制作用。分组如下：对照组（未处理）、番茄红素组（5毫克/千克/天，灌胃15天）、AFB1组（0.5毫克/千克/天，灌胃7天）和AFB1+番茄红素组。番茄红素与AFB1同时给药。与对照组相比，观察到AFB1组肝脏组织中丙二醛水平显著升高，谷胱甘肽水平降低，抗氧化酶活性降低。与对照组相比，AFB1组血浆天冬氨酸转氨酶、丙氨酸转氨酶、乳酸脱氢酶活性显著升高。与AFB1组相比，AFB1+番茄红素组丙二醛水平、血浆天冬氨酸转氨酶、丙氨酸转氨酶、乳酸脱氢酶活性显著降低，谷胱甘肽水平和抗氧化酶活性升高。本研究表明，具有抗氧化特性的番茄红素可以预防AFB1诱导的肝毒性。
