Aston C E, Sherman S L, Morton N E, Speiser P W, New M I
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York.
Am J Hum Genet. 1988 Sep;43(3):304-10.
The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.
21-羟化酶（CA21HB）基因座已被定位到6号染色体上HLA - B和HLA - DR基因座之间的区间。基于通过一名患有经典型21-羟化酶缺乏症（CA12Hd）的先证者确定的157个家庭所收集的数据，使用了几种估计遗传距离的方法，以确定CA21HB是更靠近HLA - B还是HLA - DR。结果尚无定论，但当重组频率约为0.005时，这凸显了当前估计遗传距离方法的局限性。
