21-羟化酶基因座的遗传定位：小重组频率的估计
Genetic mapping of the 21-hydroxylase locus: estimation of small recombination frequencies.
作者信息
Aston C E, Sherman S L, Morton N E, Speiser P W, New M I
机构信息
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York.
出版信息
Am J Hum Genet. 1988 Sep;43(3):304-10.
Abstract
The locus for 21-hydroxylase (CA21HB) has been mapped to the interval between the HLA-B and HLA-DR loci on chromosome 6. Several methods of estimating genetic distance were used to determine whether CA21HB is closer to HLA-B or HLA-DR based on data collected on 157 families ascertained through a proband with the classical form of 21-hydroxylase deficiency (CA12Hd). The results were inconclusive but serve to highlight the limitations of present methods of estimating genetic distance when recombination frequencies are of the order of .005.
摘要
21-羟化酶（CA21HB）基因座已被定位到6号染色体上HLA - B和HLA - DR基因座之间的区间。基于通过一名患有经典型21-羟化酶缺乏症（CA12Hd）的先证者确定的157个家庭所收集的数据，使用了几种估计遗传距离的方法，以确定CA21HB是更靠近HLA - B还是HLA - DR。结果尚无定论，但当重组频率约为0.005时，这凸显了当前估计遗传距离方法的局限性。
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