π-螺旋在 TRP 通道门控中的作用。
The role of π-helices in TRP channel gating.
机构信息
Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.
Department of Biochemistry, Duke University School of Medicine, Durham, NC, 27710, USA.
出版信息
Curr Opin Struct Biol. 2019 Oct;58:314-323. doi: 10.1016/j.sbi.2019.06.011. Epub 2019 Aug 2.
Abstract
Transient Receptor Potential (TRP) channels are a large superfamily of polymodal ion channels, which perform important roles in numerous physiological processes. The architecture of their transmembrane (TM) domains closely resembles that of voltage-gated potassium channels (K). However, recent cryoEM and crystallographic studies of TRP channels have identified π-helices in functionally important regions, and it is increasingly recognized that they utilize a distinct mechanism of gating that relies on α-to-π secondary structure transitions. Here we review our current understanding of the role of π-helices in TRP channel function and their broader impact on different classes of ion channels.
摘要
瞬时受体电位 (TRP) 通道是一大类多模式离子通道，它们在许多生理过程中发挥着重要作用。它们的跨膜 (TM) 结构域的结构与电压门控钾通道 (K) 非常相似。然而，最近对 TRP 通道的冷冻电镜和晶体学研究已经确定了功能重要区域中的π-螺旋，并且越来越认识到它们利用依赖于 α 到 π 二级结构转变的独特门控机制。在这里，我们回顾了我们目前对 π-螺旋在 TRP 通道功能中的作用的理解，以及它们对不同类离子通道的更广泛影响。
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