Instituto Federal de Educacao, Educação, Ciência e Tecnologia do Rio de Janeiro, Brazil.
Universidade Federal do Rio de Janeiro, Brazil.
FEBS J. 2019 Aug;286(15):2950-2964. doi: 10.1111/febs.14986.
In this review, we explore the roles of divalent metal ions in structure and function within the extracellular matrix (ECM), specifically, their interaction with glycosaminoglycans (GAGs) during tumor progression. Metals and GAGs have been individually associated with physiological and pathological processes, however, their combined activities in regulating cell behavior and ECM remodeling have not been fully explored to date. During tumor progression, divalent metals and GAGs participate in central processes, such as cell migration and angiogenesis, either by modulating cell surface molecules, as well as soluble signaling factors. In addition, studies on metals and polysaccharides interactions have been of great value, as they provide structural information that can be correlated with function. Finally, we believe that understanding how metals are regulated in physiological and pathological conditions is paramount for the development of new treatment strategies, as well as diagnostic and exploratory tools.
在这篇综述中，我们探讨了二价金属离子在细胞外基质（ECM）结构和功能中的作用，特别是它们在肿瘤进展过程中与糖胺聚糖（GAG）的相互作用。金属和 GAG 已分别与生理和病理过程相关，但它们在调节细胞行为和 ECM 重塑方面的联合作用尚未得到充分探索。在肿瘤进展过程中，二价金属和 GAG 通过调节细胞表面分子以及可溶性信号因子，参与细胞迁移和血管生成等核心过程。此外，关于金属和多糖相互作用的研究具有重要价值，因为它们提供了可以与功能相关联的结构信息。最后，我们认为，了解金属在生理和病理条件下是如何被调控的，对于开发新的治疗策略以及诊断和探索工具至关重要。
