Saul Meike J, Emmerich Anne C, Steinhilber Dieter, Suess Beatrix
Department of Biology, Technische Universität Darmstadt, Darmstadt, Germany.
Institute of Pharmaceutical Chemistry, Goethe Universität Frankfurt, Frankfurt, Germany.
Front Pharmacol. 2019 Jul 19;10:824. doi: 10.3389/fphar.2019.00824. eCollection 2019.
Over the last years, many microRNAs (miRNAs) have been identified that regulate the formation of bioactive lipid mediators such as prostanoids and leukotrienes. Many of these miRNAs are involved in complex regulatory circuits necessary for the fine-tuning of biological functions including inflammatory processes or cell growth. A better understanding of these networks will contribute to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer. In this review, we provide an overview of the current knowledge of miRNA regulation in eicosanoid pathways with special focus on novel miRNA functions and regulatory circuits of leukotriene and prostaglandin biosynthesis.
在过去几年中，已鉴定出许多调节生物活性脂质介质（如前列腺素和白三烯）形成的微小RNA（miRNA）。这些miRNA中的许多都参与了复杂的调节回路，这些回路对于微调包括炎症过程或细胞生长在内的生物学功能是必需的。更好地理解这些网络将有助于开发用于治疗炎症性疾病和癌症的新型治疗策略。在这篇综述中，我们概述了目前关于miRNA在类花生酸途径中调节的知识，特别关注白三烯和前列腺素生物合成的新型miRNA功能和调节回路。
