Lou Shaofeng, Wang Xinmou, Yu Zhilin, Shi Linqi
Key Laboratory of Functional Polymer Materials, Ministry of Education State Key Laboratory of Medicinal Chemical Biology Institute of Polymer Chemistry College of Chemistry Nankai University Weijin Road 94 Tianjin 300071 China.
Adv Sci (Weinh). 2019 Apr 29;6(13):1802043. doi: 10.1002/advs.201802043. eCollection 2019 Jul 3.
Programmable self-assembly of peptides into well-defined nanostructures represents one promising approach for bioinspired and biomimetic synthesis of artificial complex systems and functional materials. Despite the progress made over the past two decades in the development of strategies for precise manipulation of the self-assembly of peptides, there is a remarkable gap between current peptide assemblies and biological systems in terms of structural complexity and functions. Here, the concept of peptide tectonics for the creation of well-defined nanostructures predominately driven by the complementary association at the interacting interfaces of tectons is introduced. Peptide tectons are defined as peptide building blocks exhibiting structural complementarity at the interacting interfaces of commensurate domains and undergoing programmable self-assembly into defined supramolecular structures promoted by complementary interactions. Peptide tectons are categorized based on their conformational entropy and the underlying mechanism for the programmable self-assembly of peptide tectons is highlighted focusing on the approaches for incorporating the structural complementarity within tectons. Peptide tectonics not only provides an alternative perspective to understand the self-assembly of peptides, but also allows for precise manipulation of peptide interactions, thus leading to artificial systems with advanced complexity and functions and paves the way toward peptide-related functional materials resembling natural systems.
将肽可编程地自组装成定义明确的纳米结构，是生物启发和仿生合成人工复杂系统及功能材料的一种很有前景的方法。尽管在过去二十年里，肽自组装精确操纵策略的开发取得了进展，但目前的肽组装体与生物系统在结构复杂性和功能方面仍存在显著差距。在此，引入了肽构造学的概念，用于创建主要由构造子相互作用界面处的互补缔合驱动的定义明确的纳米结构。肽构造子被定义为在相应结构域的相互作用界面处表现出结构互补性，并通过互补相互作用进行可编程自组装形成定义明确的超分子结构的肽构建块。基于其构象熵对肽构造子进行分类，并着重介绍了在构造子中纳入结构互补性的方法，以突出肽构造子可编程自组装的潜在机制。肽构造学不仅为理解肽的自组装提供了一个新的视角，还能实现对肽相互作用的精确操纵，从而产生具有更高复杂性和功能的人工系统，并为制备类似于天然系统的肽相关功能材料铺平了道路。
